Department of Epidemiology

eBRAIN Studies

Research

Focusing on the application of epidemiology methods and cutting-edge neuroimaging methodologies in population and clinical studies to enhance etiological research and evaluation of specific therapies in the disorders of the central nervous system.

Faculty Research Trainee Research

Faculty Research

dna strand next to a human brain

Sex differences in Alzheimer's disease blood biomarkers in a Caribbean population of African ancestry: The Tobago Health Study

2024
R01 HL143793/HL/NHLBI, NIH
Caterina Rosano (MPI with Iva Miljkovic)

Alzheimer’s disease (AD) is increasing in the Caribbean, especially for persons of African ancestry (PAA) and women. However, studies have mostly utilized surveys without AD biomarkers. In the Tobago Health Study (n = 309; 109 women, mean age 70.3 ± 6.6), we assessed sex differences and risk factors for serum levels of phosphorylated tau‐181 (p‐tau181), amyloid‐beta (Aβ)42/40 ratio, glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL). Blood samples were from 2010 to 2013 for men and from 2019 to 2023 for women.
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dna strand next to a human brain

LEGENNDS: Linking Epidemiology and GEnetics of Neurodevelopmental and Neurodegenerative Disorders Study

2023-2028
R01NS131433, NIH
Andrea Rosso
B. Lee (PI)

abstract neighborhood representation

Neighborhood Environment and Risk of Cognitive Impairment in Older Adults across Southwestern Pennsylvania

2022-2023
Pitt UCSUR, Steven Manners
Faculty Development Award
Andrea Rosso

Unhealthy White Matter Connectivity, Cognition, and Racialization in Older Adults

2022-2026
5R01AG075025-02, NIABeth Shaaban

White matter hyperintensities (WMH) may promote clinical Alzheimer’s disease (AD) disparities between Black American (BA) and non-Hispanic White (nHW) populations. Using a novel measurement, unhealthy white matter connectivity (UWMC), we interrogated racialized group differences in associations between WMH in AD pathology-affected regions and cognition.
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Neural and Energetic Drivers of Performance and Perceived Fatigability in Older Adults

2022-2026
5R01AG075025-02, NIA
Caterina Rosano (PI)

Higher fatigability, the degree to which someone is physically or mentally limited due to fatigue, is common and disabling in community-dwelling older adults. While fatigue associated with a disease can be ameliorated by targeting the underlying condition, the causes and definitions of fatigability in older age are not well understood and treatments are not available.
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RC-ISC

2023-2025
5P30AG024827-19 6303, NIA
Caterina Rosano (PI)

The fundamental concepts underlying the Integrative Systems Core (ISC) are that age-related alterations in mobility and balance develop subtly, prior to overt clinical problems, and are due to multi-system interacting changes. The ISC provides state-of-the-art multidisciplinary expertise on age-related change in mobility via collaborating laboratories encompassing 1) whole-body movement and balance, 2) nervous system structure, function and energetics, and 3) cardiopulmonary and musculoskeletal structure, function and energetics.
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Myosteatosis, Cognition and Blood Biomarkers of Alzheimer's Disease in Persons of African Ancestry

2022–2025
1RF1AG077474-01, NIA
Iva Miljkovic (MPI)
Caterina Rosano (Co-PI)

Persons of African Ancestry (PAA) have higher rates of Alzheimer’s Disease and Related Dementias (ADRD) and higher rates of adiposity, compared to other races. While overall adiposity and visceral fat are known risk factors for cognitive impairment and ADRD, emerging evidence by us and others suggests that fat in muscle (myosteatosis) has independent negative effects on cognition and brain health among PAA. Since myosteatosis is greater in PAA compared to others, we propose that myosteatosis may be a novel risk factor with special relevance for ADRD in PAA. 
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Longitudinal Examination of Neighborhood Disadvantage, Cognitive Aging, and Alzheimer's Disease Risk in Disinvested, African American Neighborhoods

2022–2027
R01AG072652, NIA
Andrea Rosso (MPI)

African Americans (AAs) have significantly higher rates and earlier onset of Alzheimer’s disease and related dementias (ADRD) relative to White Americans; however, we lack a thorough understanding of how individual and neighborhood factors and their changes over the lifecourse contribute to ADRD risk in AAs. The current proposal capitalizes on an ongoing, longitudinal study to examine the impact of changing neighborhood conditions and the role of risk and protective factors in the lived experience of AAs and their influence on cognitive function and ADRD risk.
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Neurobiological Drivers of Mobility Resilience: the Dopaminergic System

2018–2023
U01AG061393, NIA
Caterina Rosano (MPI)
Andrea Rosso (Co-Investigator)

This is a longitudinal study to test the hypothesis that the striatal dopaminergic (DA) system provides resilience against the detrimental effects of common locomotor risk factors, via its connections with sensorimotor networks, thus favoring automated motor control and less engagement of attentional and prefrontal resources; we also propose a small translational study to collect pilot data on L-DOPA related changes in sensorimotor DA networks and gait.
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Population Neuroscience of Aging and Alzheimer's Disease (PNA)

2018–2023
Grant T32AG055381
Caterina Rosano (MPI)
Mary Ganguli (MPI)
Andrea Rosso (MPI)

The objective of this 5 year pre- and post-doctoral training program is to train highly talented individuals to pursue successful independent research in the etiology of Alzheimer’s Disease and other age-related dementia (ADRD). Eligible applicants are PhD graduates or candidates in Epidemiology, Neuroscience, Information Science, Biostatistics, Biomedical informatics and MD/DO graduates with training in Neurology, Psychiatry, Geriatric medicine, and related disciplines. 
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Pittsburgh Older American Independence Center

2020–2025
P30 AG024827-06, NIA 
Susan Greenspan (PI)
Caterina Rosano (Core Leader)

This Core is responsible for providing access to cutting-edge methodologies to study causes and determinants of mobility limitations, developing new assessment protocols, and supporting recruitment, retention and research training.
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Neurovascular Determinants of Cognitive Function in Adults with Sickle Cell Disease

2016–2021
R01HL127107
Enrico Novelli (PI)
Caterina Rosano (Co-Investigator)

This project is also highly innovative because it tests a new paradigm of microvascular dysfunction-related CI in SCD with state-of-the-art technology. Our scientific questions are articulated into two aims, Aim1, cross-sectional and Aim 2, longitudinal.
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Restoring Central Motor Control to Improve Community Mobility of Older Adults

2018–2022
1 R01 AG057671-01A1, NIA/NINR
Andrea Rosso (PI)
Caterina Rosano (Co-Investigator)

The results of this study will provide evidence of the extent to which Motor Skill Training can improve real world measures of community mobility, quantify the contribution from restoration of central motor control, and identify the influence from other characteristics of the person and their environment.
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Locomotor Adaptability for Community Mobility of Older Adults: The Role of Gait Automaticity

2020–2022
Pitt Momentum Funds
Andrea Rosso (Co-Investigator)

Exposure to split-belt walking, in which legs move at different speeds, improves locomotor adaptability in older adults, but the underlying mechanisms of these improvements are unknown. Extent of gait automaticity may be an important neural mechanism of locomotor adaptability. We will also determine cognitive correlates of locomotor adaptability and whether improving locomotor adaptability changes mobility outcomes.
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Preventing Cognitive Decline and Dementia Among Older Chinese Immigrants: The Role of Activity, Engagement, Immigration Experience, and Neighborhood Environments

2020–2024
1R01AG067548-01
Fengyan Tang (PI)
Andrea Rosso (Co-Investigator)

This project will conduct the first comprehensive epidemiological study to investigate change trajectories of cognitive function and the preventive effects of activity engagement profiles, examining the risk and protective factors associated with immigration experience and neighborhood contexts in the aging Chinese immigrant population. 
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Environmental Challenges and the Aging Brain: Implications for Community Mobility

2016–2022
1K01AG053431-01, NIA
Andrea Rosso (PI)

This career development award proposes to assess age-related changes in the brain that may be a key determinant of the ability to remain mobile in complex community environments through utilization of a study design that incorporates community-based environmental challenges and real-time functional brain imaging while participants are walking.
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Neighborhoods, Cognitive Aging and Modifiable Risk Factors

2018–2022
1R01AG055404-01A1, NIA
Michelle Carlson (PI)
Andrea Rosso (Co-Investigator)

Long-term exposure to neighborhood disadvantage may serve as a common cause of individual risk factors and neurocognitive and functional health, particularly in groups at elevated risk for Alzheimer’s disease. We will examine the influence of a range of neighborhood factors on long-term trajectories of cognitive and functional aging prior to the onset of AD in the Cardiovascular Health Study.
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ADRD Supplement: Urban Revitalization and Long-term Effects on Diet, Economic, and Health Outcomes

2018–2021
R01 CA149105-07S1, NIA
Tamara Dubowitz (PI) 
Andrea Rosso (Co-Investigator)

This supplement will add measures of cognitive function and clinically adjudicated Mild Cognitive Impairment and Alzheimer’s Disease to our ongoing NCI-funded study that is following a cohort of mid- to late-life African Americans residing in two low-income neighborhoods.
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ADRD Supplement: Natural Experiment of Neighborhood Revitalization and Cardiometabolic Health

2018–2021
R01 HL131531-03S1, NIA
Wendy Troxel (MPI)
Tiffany Gary-Webb (MPI)
Andrea Rosso (Co-Investigator)

This study will add cognitive assessments to an ongoing NHLBI-funded study (HL131531) which is following a sample of low- income, mid- to late- life African American residents. Understanding the impact of cumulative, race-relevant stressors on cognitive outcomes is critical in order to identify individual and policy-level interventions to mitigate pervasive racial/ ethnic disparities in dementia and poor cognitive functioning in late life.
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Cognitive Decline, Brain Aging, Physical Environment, and Mobility

2016–2018
R21 AG054666-01, NIA
Andrea Rosso (PI)

This proposal aims to understand better the environmental contributors to mobility limitations that could be the target of future population-level prevention strategies. In particular, we aim to understand how age-related cognitive declines can make some individuals more vulnerable to the mobility-limiting aspects of their environments.
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Identification of Factors Associated with Subsequent Alzheimer's Disease Diagnosis Using Machine Learning Over Complex Large-scale Longitudinal Health Data

2020–2021
Momentum Funds Teaming Grant
University of Pittsburgh Senior Vice Chancellor’s Office
Richard Boyce (PI) 
Beth Shaaban (Co-Investigator)

The aim of this project is to identify antecedents of Alzheimer’s disease in the University of Pittsburgh Medical Center electronic health records, which warrant additional scrutiny as possible risk or protective protectors for disease onset using case-control and machine learning study designs and incorporating graphical causal models.
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Pathways of Beneficial Effects of a Physical Activity Intervention on Hippocampal Atrophy Among Older Adults

2016–2018
F31AG054084, NIA
Beth Shaaban (PI) 

This award funded my final two years of doctoral epidemiology training to develop expertise in the promotion of neurovascular integrity for the prevention of cognitive decline and disorders in very old adults. This research evaluated the pathways by which physical activity impacts the hippocampus and cerebral small vein integrity of older adults.
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Ultra-high-field Neuroimaging in Elderly After a Two-year Exercise Intervention

2014–2018
1 R01 AG044474-04, NIA
Caterina Rosano (PI)
Howard Aizenstein (PI)

The project leverages the LIFE-M 2 year-long physical activity RCT to examine physical activity-related effects on hippocampal formation and specifically in the dentate gyrus, by applying 7-Tesla ultra-high field technology.
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Retinal Imaging Markers of Cognition in Adults with T1D

2015–2017
R21 DK107926-01
Caterina Rosano (PI)

Examined the relationships, both cross-sectionally and change over time, between neurocognitive complications (e.g., brain imaging markers, psychomotor speed, cognitive impairment) with measures of retinal vascular health (e.g., retinal vessels diameter, retinopathy) in middle-aged adults with childhood onset Type 1 Diabetes.
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Healthy Brain Project 2 - Resilience to Mobility Impairment: Neural Correlates and Protective Factors

2011–2017
1 R01 AG037451-01A1, NIA
Caterina Rosano (PI)

This is a longitudinal neuroepidemiological study to identify the brain characteristics and risk factors of older adults who have maintained good mobility in the face of substantial structural brain abnormalities.
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Imaging Biomarkers of Accelerated Brain Aging in Type-1 Diabetes

2010–2016
R01 DK089028-04, NIDDK
Caterina Rosano (PI)

This research will quantify the nature, severity and risk factors of brain abnormalities in the ongoing longitudinal Epidemiology of Diabetes Complications (EDC) cohort study as adults with Type 1 Diabetes (T1D) are increasingly more likely to develop brain abnormalities in addition to multiple micro- and macro-vascular complications.
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Healthy Brain Project 1 - Brain Anatomical Correlates of Mobility Control in the Oldest Old

2007–2012
1 R01 AG029232-01
Caterina Rosano (PI)

This project aims to investigate the longitudinal association of focal brain magnetic resonance imaging (MRI) abnormalities in GM and WM with age-related mobility impairment in gait speed and balance in a large cohort of community-dwelling older adults from the Health Aging Body Composition Study (Health ABC).
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In our Trainees’ words: A Catalogue of our Publications

Emma Monroe Baillargeon, PT, DPT, PhD

Postdoctoral Scholar

Emma's listed publications explore various aspects of aging, including gait speed, prefrontal cortex function, motor control, shoulder strength, and dual-task performance, with a focus on how these factors relate to physical and cognitive health in older adults through interventions, assessments, and neural activity analysis.
  1. Baillargeon, Emma & Jones, Nancy & Rosso, Andrea & Brach, Jennifer. (2024). GAIT SPEED IMPLEMENTATION IN TWO GERIATRIC CLINICS IS CONSISTENT ACROSS PATIENTS AND VISIT TYPES. Innovation in Aging. 8. 584-584. 10.1093/geroni/igae098.1913.
  2. Rosso, Andrea & Baillargeon, Emma & Huppert, Theodore & Bohnen, Nicholaas & Chahine, Lana & Rosano, Caterina. (2024). RELATION OF PREFRONTAL CORTEX FUNCTION WITH DUAL-TASK GAIT DEPENDS ON POSTDORSAL CAUDATE DOPAMINE. Innovation in Aging. 8. 323-324. 10.1093/geroni/igae098.1057.
  3. Baillargeon, Emma & Seitz, Amee & Ludvig, Daniel & Nicolozakes, Constantine & Deshmukh, Swati & Perreault, Eric. (2024). Older age is associated with decreased overall shoulder strength but not direction-specific differences in the three-dimensional feasible torque space. Journal of Electromyography and Kinesiology. 77. 102889. 10.1016/j.jelekin.2024.102889.
  4. Rosso, Andrea & Baillargeon, Emma & Perera, Subashan & Vanswearingen, Jessie & Rosano, Caterina & Huppert, Theodore & Brach, Jennifer. (2024). Prefrontal cortex activation while walking did not change but gait speed improved after a randomized physical therapy intervention. Aging Clinical and Experimental Research. 36. 10.1007/s40520-023-02666-7.
  5. Liu, Shuqi & Rosso, Andrea & Baillargeon, Emma & Weinstein, Andrea & Rosano, Caterina & Torres-Oviedo, Gelsy. (2024). Novel attentional gait index reveals a cognitive ability-related decline in gait automaticity during dual-task walking. Frontiers in aging neuroscience. 15. 1283376. 10.3389/fnagi.2023.1283376.
  6. Baillargeon, Emma & Huppert, Theodore & Rosano, Caterina & Rosso, Andrea. (2023). HETEROGENEITY OF PREFRONTAL CORTICAL ACTIVITY DURING WALKING AMONG OLDER ADULTS. Innovation in Aging. 7. 168-169. 10.1093/geroni/igad104.0551.
  7. Rosso, Andrea & Baillargeon, Emma & Moored, Kyle & Crane, Breanna & Carlson, Michelle & Huppert, Theodore & Brach, Jennifer & Rosano, Caterina. (2023). GAIT AUTOMATICITY AND COMMUNITY MOBILITY OF OLDER ADULTS. Innovation in Aging. 7. 167-168. 10.1093/geroni/igad104.0548.
  8. Thomas, Christina & Johnson, Brianna & Baillargeon, Emma & Heckman, Rosalind. (2023). Motor Preparation At The Shoulder Can Be Investigated Using StartReact: 708. Medicine & Science in Sports & Exercise. 55. 241-242. 10.1249/01.mss.0000981968.65770.03.
  9. Liu, Shuqi & Rosso, Andrea & Baillargeon, Emma & Weinstein, Andrea & Torres-Oviedo, Gelsy. (2023). Novel automaticity index characterizing dual task walking reveals a cognitive ability-related decline in gait automaticity. bioRxiv : the preprint server for biology. 10.1101/2023.07.31.551290.
  10. Bohlke, Kayla & Perera, Subashan & Baillargeon, Emma & Redfern, Mark & Sparto, Patrick & Sejdic, Ervin & Rosso, Andrea. (2023). Exercise interventions, postural control, and prefrontal cortex activation in older adults. Brain and cognition. 171. 106063. 10.1016/j.bandc.2023.106063.
  11. Suri, Anisha & Vanswearingen, Jessie & Baillargeon, Emma & Crane, Breanna & Moored, Kyle & Carlson, Michelle & Dunlap, Pamela & Donahue, Patrick & Redfern, Mark & Brach, Jennifer & Sejdic, Ervin & Rosso, Andrea. (2023). Association Of Gait Quality with Daily-Life Mobility: An Actigraphy and Global Positioning System Based Analysis in Older Adults. IEEE transactions on bio-medical engineering. PP. 10.1109/TBME.2023.3293752.
  12. Baillargeon, Emma & Suri, Anisha & Huppert, Theodore & Sejdic, Ervin & Rosso, Andrea. (2022). DUAL-TASK CHANGES IN PREFRONTAL ACTIVATION AND GAIT QUALITY IN OLDER ADULTS. Innovation in Aging. 6. 332-332. 10.1093/geroni/igac059.1311.
  13. Rosso, Andrea & Fraser, Sarah & Holtzer, Roee & Salzman, Talia & Rosano, Caterina & Baillargeon, Emma & Sprague, Briana & Tian, Qu. (2022). NOVEL INSIGHTS INTO GAIT, MOTOR CONTROL, AND THE BRAIN: IMPLICATIONS FOR COGNITIVE AGING. Innovation in Aging. 6. 331-332. 10.1093/geroni/igac059.1308.
  14. Nicolozakes, Constantine & Sohn, M. Hongchul & Baillargeon, Emma & Lipps, David & Perreault, Eric. (2022). Stretch reflex gain scaling at the shoulder varies with synergistic muscle activity. Journal of neurophysiology. 128. 10.1152/jn.00259.2022.
  15. Coats-Thomas, Margaret & Baillargeon, Emma & Ludvig, Daniel & Marra, Guido & Perreault, Eric & Seitz, Amee. (2022). No Strength Differences Despite Greater Posterior Rotator Cuff Intramuscular Fat in Patients With Eccentric Glenohumeral Osteoarthritis. Clinical Orthopaedics & Related Research. Publish Ahead of Print. 10.1097/CORR.0000000000002253.
  16. Baillargeon, Emma & Suri, Anisha & Chen, Nemin & Zhu, Xiaonan & Rosano, Caterina & Sejdic, Ervin & Huppert, Theodore & Rosso, Andrea. (2021). Prefrontal Activation is Associated With Gait Quality During an Attentional Task in Older Adults. Innovation in Aging. 5. 987-987. 10.1093/geroni/igab046.3516.
  17. Nicolozakes, Constantine & Ludvig, Daniel & Baillargeon, Emma & Perreault, Eric & Seitz, Amee. (2021). Muscle Contraction Has a Reduced Effect on Increasing Glenohumeral Stability in the Apprehension Position. Medicine & Science in Sports & Exercise. Publish Ahead of Print. 10.1249/MSS.0000000000002708. 

Greta Jianjia Cheng, MSW, MPH

PhD Student

Greta focused on studies that examine how depression, physical activity, and social factors affect mental health in older adults.
  1. Li, Lydia & Cheng, Greta & Xu, Hongwei & Zhang, Zhenmei & Liu, Jinyu & Conwell, Yeates. (2022). Depression Is Associated With Myocardial Infarction Within a 2-Year Period Among Adults in China. Asia Pacific Journal of Public Health. 34. 101053952210953. 10.1177/10105395221095331.
  2. Cheng, Greta & Kobayashi, Lindsay. (2021). Associations Between Comorbidity and Depressive Symptoms During COVID-19: Variation by Social Isolation?. Innovation in Aging. 5. 39-39. 10.1093/geroni/igab046.144.
  3. Nicklett, Emily & Cheng, Greta. (2021). Predictors of Food Insecurity Before and During COVID-19 Among Middle-Aged and Older Adults. Innovation in Aging. 5. 956-956. 10.1093/geroni/igab046.3420.
  4. Cheng, Greta & Nicklett, Emily. (2020). Associations Between Physical Activity and Living Alone: Are There Differences by Gender?. Innovation in Aging. 4. 495-496. 10.1093/geroni/igaa057.1601.
  5. Xiang, Xiaoling & Yang, Yong & Cheng, Greta & An, Ruopeng. (2020). The Impact of Late-Life Disability Spectrum on Depressive Symptoms: A Fixed-Effects Analysis of Panel Data. The journals of gerontology. Series B, Psychological sciences and social sciences. 76. 10.1093/geronb/gbaa060.
  6. Nicklett, Emily & Chen, Jieling & Xiang, Xiaoling & Abrams, Leah & Sonnega, Amanda & Johnson, Kimson & Cheng, Greta & Assari, Shervin. (2020). Associations Between Diagnosis with Type 2 Diabetes and Changes in Physical Activity among Middle-Aged and Older Adults in the United States. Innovation in Aging. 4. 10.1093/geroni/igz048.
  7. Cheng, Greta & Choi, Jungtae & Li, Lydia. (2019). PREVALENCE AND MANAGEMENT OF HYPERTENSION AMONG MIDDLE-AGED AND OLDER ADULTS IN CHINA. Innovation in Aging. 3. S123-S123. 10.1093/geroni/igz038.451.
  8. Xiang, Xiaoling & Cheng, Greta & Zuverink, Ashley & Wang, Xiafei. (2019). Perceptions and practice behaviors regarding late-life depression among private duty home care workers: a mixed-methods study. Aging & Mental Health. 24. 1-8. 10.1080/13607863.2019.1636207.
  9. Xiang, Xiaoling & Cheng, Greta. (2019). Trajectories of major depression in middle‐aged and older adults: A population‐based study. International Journal of Geriatric Psychiatry. 34. 10.1002/gps.5161. 
Mauricio Gil-Silva

Chen Hu, BS, MS

MD/PhD Student

The following articles highlight Chen's exploration of diverse neurological topics, including trends in gender and racial diversity in neurology faculty, the impact of multiple sclerosis, biomarkers in disease progression, and therapeutic insights in conditions like stiff person syndrome, underscore the evolving landscape of neurodegenerative disease research and clinical care.
  1. Tsai, Wendy & Hu, Chen & Ding, Jeffrey & Bui, Esther & Pikula, Aleksandra & Field, Thalia & Tiwana, Sabeen & Siddiqi, Javed & Khosa, Faisal. (2024). Trends in Gender, Racial, and Ethnic Representation Among US Neurology Faculty. JAMA Neurology. 82. 10.1001/jamaneurol.2024.3909.
  2. Hu, Chen & Vasileiou, Eleni & Salter, Amber & Marrie, Ruth & Kowalec, Kaarina & Fitzgerald, Kathryn. (2024). Evidence of symptom specificity for depression in multiple sclerosis: A two sample Mendelian randomization study. Multiple Sclerosis and Related Disorders. 91. 105866. 10.1016/j.msard.2024.105866.
  3. Koshorek, Jacqueline & Hu, Chen & Wang, Yujie & Grkovski, Risto & Lin, Doris & Fitzgerald, Kathryn & Newsome, Scott & Mowry, Ellen. (2024). Relevance of antinuclear antibody in diagnosis and characteristics of multiple sclerosis. Multiple sclerosis and related disorders. 87. 105639. 10.1016/j.msard.2024.105639.
  4. Simpson, Alexandra & Hu, Chen & Mowry, Ellen & Naismith, Robert & Fitzgerald, Kathryn & Nourbakhsh, Bardia. (2024). Structural MRI measures are associated with fatigue severity and persistence in a large, real-world cohort of people with multiple sclerosis. Multiple Sclerosis Journal. 30. 738-746. 10.1177/13524585241239473.
  5. Rjeily, Nicole & Sanjayan, Muraleetharan & Guha Niyogi, Pratim & Dewey, Blake & Lee, Alexandra & Hulett, Christy & Dagher, Gabriella & Hu, Chen & Mazur, Rafal & Kenney, Elena & Brennan, Erin & DuVal, Anna & Calabresi, Peter & Zipunnikov, Vadim & Fitzgerald, Kathryn & Mowry, Ellen. (2024). Accelerometry-assessed Physical Activity and Circadian Rhythm to Detect Clinical Disability Status in Multiple Sclerosis: A Cross-sectional Study (Preprint). JMIR mHealth and uHealth. 10.2196/57599.
  6. Wang, Yujie & Hu, Chen & Aljarallah, Salman & Reyes Mantilla, Maria & Mukharesh, Loulwah & Simpson, Alexandra & Roy, Shuvro & Harrison, Kimystian & Shoemaker, Thomas & Comisac, Michael & Balshi, Alexandra & Obando, Danielle & Pimentel Maldonado, Daniela & Koshorek, Jacqueline & Snoops, Sarah & Fitzgerald, Kathryn & Newsome, Scott. (2023). Expanding clinical profiles and prognostic markers in stiff person syndrome spectrum disorders. Journal of Neurology. 271. 1-12. 10.1007/s00415-023-12123-0.
  7. Sotirchos, Elias & Hu, Chen & Smith, Matthew & Lord, Hannah-Noelle & DuVal, Anna & Arrambide, Georgina & Montalban, Xavier & Akgün, K. & Ziemssen, Tjalf & Naismith, Robert & Hersh, Carrie & Hyland, Megan & Krupp, Lauren & Nicholas, Jacqueline & Bermel, Robert & Mowry, Ellen & Calabresi, Peter & Fitzgerald, Kathryn. (2023). Agreement Between Published Reference Resources for Neurofilament Light Chain Levels in People With Multiple Sclerosis. Neurology. 101. 10.1212/WNL.0000000000207957. 10.1212/WNL.0000000000207957. 
  8. Mercure-Corriveau, Nicolas & Roy, Shuvro & Hu, Chen & Crowe, Elizabeth & Zhu, Xianming & Obando, Danielle & Patel, Eshan & Tobian, Aaron & Wang, Yujie & Bloch, Evan & Newsome, Scott. (2023). Therapeutic plasma exchange in the management of stiff person syndrome spectrum disorders: a case series and review of the literature. Therapeutic Advances in Neurological Disorders. 16. 10.1177/17562864231180736.
  9. Ehrhardt, Henrik & Lambe, Jeffrey & Moussa, Hussein & Vasileiou, Eleni & Kalaitzidis, Grigorios & Murphy, Olwen & Filippatou, Angeliki & Pellegrini, Nicole & Douglas, Morgan & Davis, Simidele & Nagy, Natalia & Quiroga, Agustina & Hu, Chen & Lee, Alexandra & Duval, Anna & Fitzgerald, Kathryn & Prince, Jerry & Calabresi, Peter & Sotirchos, Elias & Saidha, Shiv. (2023). Effects of Ibudilast on Retinal Atrophy in Progressive Multiple Sclerosis Subtypes: Post-Hoc Analyses of the SPRINT-MS Trial. Neurology. 101. 10.1212/WNL.0000000000207551. 10.1212/WNL.0000000000207551.
  10. Pimentel Maldonado, Daniela & Balshi, Alexandra & Hu, Chen & Fitzgerald, Kathryn & Koshorek, Jacqueline & Reyes Mantilla, Maria & Obando, Danielle & Wang, Yujie & Newsome, Scott. (2023). Respiratory Symptoms are Common in Stiff Person Syndrome Spectrum Disorders and are Associated with Number of Body Regions Involved. European journal of neurology. 30. 10.1111/ene.15825.
  11. Roy, Shuvro & Hu, Chen & Wang, Yujie & Fitzgerald, Kathryn & Newsome, Scott. (2023). Identifying Key Components for Diagnosing Stiff Person Syndrome Spectrum Disorders: A Sensitivity and Specificity Study (P4-5.018). Neurology. 100. 2704. 10.1212/WNL.0000000000202736.
  12. Harrison, Kimystian & Hu, Chen & Aljarallah, Salman & Wang, Yujie & Fitzgerald, Kathryn & Newsome, Scott. (2023). Rituximab is Associated with Limiting Progression in Individuals with Stiff Person Syndrome Spectrum Disorders (S40.002). Neurology. 100. 3826. 10.1212/WNL.0000000000203551.
  13. Wang, Yujie & Hu, Chen & Mukharesh, Loulwah & Aljarallah, Salman & Reyes Mantilla, Maria & Comisac, Michael & Balshi, Alexandra & Obando, Danielle & Snoops, Sarah & Fitzgerald, Kathryn & Newsome, Scott. (2023). Early Predictors of Future Disability in Stiff Person Syndrome Spectrum Disorders (S40.001). Neurology. 100. 2684. 10.1212/WNL.0000000000202721.
  14. Hu, Chen & Dewey, Blake & Mowry, Ellen & Fitzgerald, Kathryn. (2023). Deep gray matter substructure volumes and depressive symptoms in a large multiple sclerosis cohort. Multiple Sclerosis Journal. 29. 809-818. 10.1177/13524585221148144.
  15. Singh, Namrata & Madhira, Vithal & Hu, Chen & Olex, Amy & Bergquist, Tim & Fitzgerald, Kathryn & Huling, Jared & Patel, Rena & Singh, Jasvinder. (2022). Rituximab is associated with worse COVID-19 outcomes in patients with rheumatoid arthritis: A retrospective, nationally sampled cohort study from the U.S. National COVID Cohort Collaborative (N3C). Seminars in Arthritis and Rheumatism. 58. 152149. 10.1016/j.semarthrit.2022.152149.
  16. Kalaitzidis, Grigorios & Pellegrini, Nicole & Nagy, Natalia & Vasileiou, Eleni & Ehrhardt, Henrik & Reppen, Abbey & Murphy, Olwen & Moussa, Hussein & Filippatou, Angeliki & Lambe, Jeffrey & DuVal, Anna & Fioravante, Nicholas & Kwakyi, Ohemaa & Nguyen, James & Davis, Simidele & Douglas, Morgan & Ramirez, Alexandra & Ecoff, Katie & Valenzuela, Alyssandra & Calabresi, Peter. (2022). Effects of Myopia on Rates of Change in Optical Coherence Tomography Measured Retinal Layer Thicknesses in People with Multiple Sclerosis and Healthy Controls. Current eye research. 48. 1-8. 10.1080/02713683.2022.2149806.
  17. Vasileiou, Eleni & Hu, Chen & Bernstein, Charles & Lublin, Fred & Wolinsky, Jerry & Cutter, Gary & Sotirchos, Elias & Kowalec, Kaarina & Salter, Amber & Saidha, Shiv & Mowry, Ellen & Calabresi, Peter & Marrie, Ruth & Fitzgerald, Kathryn. (2022). Association of Vitamin D Polygenic Risk Scores and Disease Outcome in People With Multiple Sclerosis. Neurology(R) neuroimmunology & neuroinflammation. 10. 10.1212/NXI.0000000000200062.
  18. Vasileiou, Eleni & Hu, Chen & Kalaitzidis, Grigorios & Ehrhardt, Henrik & Moussa, Hussein & Ladakis, Dimitrios & Ahmadi, Gelareh & Sotirchos, Elias & Saidha, Shiv & Mowry, Ellen & Calabresi, Peter & Dickerson, Aisha & Fitzgerald, Kathryn. (2022). Long-term exposure to ambient air pollution is associated with increased neuronal injury in people with multiple sclerosis. 
Laura Alejandra Ramirez Tirado, MD, MSc.

Laura Alejandra Ramirez Tirado, MD, MSc

PhD Student

Alejandra's research covers how drug efficacy, biomarkers, immunotherapy, and radiotherapy may improve patient outcomes for non-small cell lung cancer treatments.
  1. Arrieta, Oscar & Vega-González, María & López-Macías, Diego & Martínez-Hernández, Jorge & Bacon, Ludwing & Macedo-Pérez, Eleazar & Ramírez-Tirado, Laura-Alejandra & Flores, Diana & Garza, Jaime. (2015). Randomized, Open-label Trial Evaluating the Preventive Effect of Tetracycline on Afatinib Induced-Skin Toxicities in Non-Small Cell Lung Cancer Patients. Lung Cancer. 10.1016/j.lungcan.2015.03.019.
  2. Barrera, Lourdes & Servin, Edgar & Barrera, Alejandra & Ramírez-Tirado, Laura-Alejandra & Salinas-Parra, Fernanda & Bañales-Mendez, Jose-Luis & Sandoval-Ríos, Marisol & Arrieta, Oscar. (2014). Cytokines profile determined by data mining analysis set into clusters Non-Small Cell Lung Cancer patients according to prognosis. Annals of Oncology. 26. 10.1093/annonc/mdu549.
  3. Ramírez-Tirado, Laura-Alejandra & Tirado-Gómez, Laura & Lopez-Cervantes, Malaquías. (2014). [Inequality in primary care interventions in maternal and child health care in Mexico]. Revista Panamericana de Salud Pública. 35. 235-41.
  4. Arrieta, Oscar & Medina, Luis & Estrada Lobato, Enrique & Ramírez-Tirado, Laura-Alejandra & Mendoza-García, Víctor-Osvaldo & Garza, Jaime. (2014). High liposomal doxorubicin tumour tissue distribution, as determined by radiopharmaceutical labelling with Tc-99m-LD, is associated with the response and survival of patients with unresectable pleural mesothelioma treated with a combination of liposomal doxorubicin and cisplatin. Cancer chemotherapy and pharmacology. 74. 10.1007/s00280-014-2477-x.
  5. Turcott, Jenny & Martínez-Sámano, Julio Eduardo & Cardona, Andrés & Samtani, Suraj & Ramírez-Tirado, Laura-Alejandra & Zatarain-Barrón, Zyanya & Barron, Feliciano & Corrales, Luis & Martin, Claudio & Barragán Castillo, Pablo Alan & Ruiz Patiño, Alejandro & Flores, Diana & Arrieta, Oscar. (2020). The Role of a Cachexia Grading System in Patients with Non-Small Cell Lung Cancer Treated with Immunotherapy: Implications for Survival. Nutrition and Cancer. 73. 1-8. 10.1080/01635581.2020.1769691.
  6. Arrieta, Oscar & Barron, Feliciano & Ramírez-Tirado, Laura-Alejandra & Zatarain-Barrón, Zyanya & Cardona, Andrés & Díaz-García, Diego & Yamamoto-Ramos, Masao & Mota-Vega, Beatriz & Carmona Gonzalez, Carlos & Álvarez, Marco Polo & Bautista, Yolanda & Aldaco, Fernando & Gerson, Raquel & Rolfo, Christian & Rosell, Rafael. (2020). Efficacy and Safety of Pembrolizumab Plus Docetaxel vs Docetaxel Alone in Patients With Previously Treated Advanced Non–Small Cell Lung Cancer. The PROLUNG Phase 2 Randomized Clinical Trial. JAMA Oncology. 6. 10.1001/jamaoncol.2020.0409.
  7. Arrieta, Oscar & Ramírez-Tirado, Laura-Alejandra & Zatarain-Barrón, Zyanya. (2020). Metformin Plus Tyrosine Kinase Inhibitors in Epidermal Growth Factor Receptor–Mutated Non–Small Cell Lung Cancer—Reply. JAMA Oncology. 6. 10.1001/jamaoncol.2020.0062.
  8. López‐Salazar, Javier & Ramírez-Tirado, Laura-Alejandra & Gómez‐Contreras, Nora & Pacheco‐Bravo, Irlanda & Cortés, Evelyn & Gallardo, Dolores & Arrieta, Oscar & Cesarman, Gabriela & Arauz, Rafael. (2020). Cancer‐associated prothrombotic pathways: leucocytosis, but not thrombocytosis, correlates with venous thromboembolism in women with ovarian cancer. Internal Medicine Journal. 50. 366-370. 10.1111/imj.14762.
  9. Arrieta, Oscar & Ramírez-Tirado, Laura-Alejandra & Caballé‐Perez, Enrique & Mejia‐Perez, Alberto & Zatarain‐Barrón, Zyanya & Cardona, Andrés & Lozano-Ruiz, Francisco & Segura-Gonzalez, Manuel & Cruz Rico, Graciela & Magos, Federico & Rosell, Rafael. (2020). Response rate of patients with baseline brain metastases from recently diagnosed non‐small cell lung cancer receiving radiotherapy according to EGFR , ALK and KRAS mutation status. Thoracic Cancer. 11. 10.1111/1759-7714.13359.
  10. Arrieta, Oscar & Avilés-Salas, Alejandro & Orozco‐Morales, Mario & Hernández-Pedro, Norma & Cardona, Andrés & Barrios Bernal, Pedro & Soca Chafre, Giovanny & Cruz Rico, Graciela & Peña‐Torres, María & Moncada‐Claudio, Guadalupe & Ramírez-Tirado, Laura-Alejandra. (2020). Association between CD47 expression, clinical characteristics and prognosis in patients with advanced non-small cell lung cancer. Cancer Medicine. 9. 1-13. 10.1002/cam4.2882.
  11. Ramírez-Tirado, Laura-Alejandra & Barron, Feliciano & Zatarain, Lucia & Álvarez, Marco Polo & Meneses-García, A.A. & Ruíz-Godoy, Luz & Salazar, J. & Torres, D.I. & Millan, M.F. & Hernández, J.Á & Cardona, Andrés & Arrieta, Oscar. (2019). P2.26 Budget Impact Analysis of Immunotherapy as Second-line Treatment of NSCLC at MX’s National Institute of Cancer. Journal of Thoracic Oncology. 14. S1196. 10.1016/j.jtho.2019.09.191.
  12. Barron, Feliciano & Mota, B. & Ramírez-Tirado, Laura-Alejandra & Zatarain, Lucia & López-Sánchez, Dennis & Álvarez, Marco Polo & Arrieta, Oscar. (2019). P2.24 Lung Immune Prognostic Index in Patients with Non-small Cell Lung Cancer Treated with Either Chemo or Immunotherapy. Journal of Thoracic Oncology. 14. S1195. 10.1016/j.jtho.2019.09.189.
  13. Blake-Cerda, M. & Lozano-Ruiz, Francisco & Magos, Federico & De la mata, María & Diaz-Garcia, D.A. & Ramírez-Tirado, Laura-Alejandra & Góngora, M.F. & Barron, Feliciano & Gerson, R. & Arrieta, Oscar. (2019). P2.08-04 Stereotactic Ablative Radiation Therapy to Lung Metastases Associates with Better Outcomes in Oligometastatic Lung Cancer: Prospective Study. Journal of Thoracic Oncology. 14. S766-S767. 10.1016/j.jtho.2019.08.1647.
  14. Turcott, Jenny & Cardona, A.F. & Ramírez-Tirado, Laura-Alejandra & Barrón, Z.L. & Barron, Feliciano & Corrales, Luis & Martin, Claudio & Barragán Castillo, Pablo Alan & Flores, Diana & Ruiz Patiño, Alejandro & Arrieta, Oscar. (2019). MA07.08 The Role of a Cachexia Grading System in Patients with NSCLC Treated with Immunotherapy: Implications for Response and Survival. Journal of Thoracic Oncology. 14. S275. 10.1016/j.jtho.2019.08.552.
  15. Hernández-Pedro, Norma & Orozco-Morales, M. & Avilés-Salas, Alejandro & Ramírez-Tirado, Laura-Alejandra & Barrios Bernal, Pedro & Arrieta, Oscar. (2019). EP1.12-16 CD47 Expression and Prognosis in Patients with Small Cell Lung CancerCD47 Expression and Prognosis in Patients with Small Cell Lung Cancer. Journal of Thoracic Oncology. 14. S1022. 10.1016/j.jtho.2019.08.2261.
  16. Ramírez-Tirado, Laura-Alejandra & Guzmán, S. & Goycochea-Robles, C. & Barron, Feliciano & Flores, Diana & Arrieta, Oscar. (2019). P2.14-43 Cost-Effectiveness of 1st-Line Treatment EGFR-TKIs for Advanced NSCLC Patients Harboring EGFR Mutation in Mexico. Journal of Thoracic Oncology. 14. S846. 10.1016/j.jtho.2019.08.1828.
  17. Diaz-Garcia, D.A. & Ramírez-Tirado, Laura-Alejandra & Avilés-Salas, Alejandro & Cardona, Andrés & Rodriguez-Rios, A. & Barron, Feliciano & Arrieta, Oscar. (2019). Prognostic Impact of LKB1 Expression in Advanced Non-Small-Cell Lung Cancer. Journal of Thoracic Oncology. 14. S780-S781. 10.1016/j.jtho.2019.08.1677.
  18. Arrieta, Oscar & Barron, Feliciano & Carmona Gonzalez, Carlos & Ramírez-Tirado, Laura-Alejandra & Barrón, Z.L. & Cardona, A.F. & Bautista, Y. & Aldaco, F. & Lázaro-León, Jesús & Baez, R. & Gerson, R. & Blanco, C.. (2019). MA11.03 Pembrolizumab Plus Docetaxel Increases Progression-Free Survival Compared with Docetaxel Alone in Previously Treated Advanced Non-Small Cell Lung Cancer Patients. Journal of Thoracic Oncology. 14. S291. 10.1016/j.jtho.2019.08.585.
  19. Turcott, Jenny & Martínez-Sámano, Julio Eduardo & Samtani, Suraj & Ramírez-Tirado, Laura-Alejandra & Barron, Feliciano & Corrales, Luis & Martin, Claudio & Alan, Pablo & Barragán Castillo, Pablo Alan & Flores, Diana & Ruiz Patiño, Alejandro & Zatarain, Lucia & Cardona, Andrés & Arrieta, Oscar. (2019). The role of a cachexia grading system in patients with non-small cell lung cancer treated with immunotherapy: implications for survival DISCLOSURE STATEMENT.
  20. Ramírez-Tirado, Laura-Alejandra & Avilés, Alejandro & Cardona, Andrés & Barron, Feliciano & Arrieta, Oscar. (2019). Prognostic impact of LKB1 expression in advanced Non-Small-Cell Lung Cancer.
  21. Arrieta, Oscar & Barron, Feliciano & Carmona Gonzalez, Carlos & Ramírez-Tirado, Laura-Alejandra & Lucia, Zyanya & Barrón, Zatarain & Bautista, Yolanda & Aldaco, Fernando & Lázaro-León, Jesús & Baez, Renata & Gerson, Raquel & Blanco, Carolina & Cardona, Andrés. (2019). Pembrolizumab Plus Docetaxel (PD) Increases Progression- Free Survival (PFS) Compared with Docetaxel Alone (D) in Previously Treated Advanced Non-Small Cell Lung Cancer (NSCLC) Patients DISCLOSURE SLIDE.
  22. Sánchez-Reyes, Roberto & Varela-Santoyo, Edgar & Ramírez-Tirado, Laura-Alejandra & Bautista, Dafne & Barron, Feliciano & Corrales, Luis & Motola-Kuba, Daniel & Martin, Claudio & Cardona, Andrés & Arrieta, Oscar. (2019). Normalization of carcinoembryonic antigen levels are associated with a survival improvement in advanced non-small cell lung cancer patients Roberto Sánchez-Reyes, Instituto Nacional de Cancerología, México.
  23. Arrieta, Oscar & Barron, Feliciano & Padilla, Miguel-Ángel & Avilés-Salas, Alejandro & Ramírez-Tirado, Laura-Alejandra & Arguelles, Manuel & Vergara, Edgar & Zatarain-Barrón, Zyanya & Hernández-Pedro, Norma & Cardona, Andrés & Cruz Rico, Graciela & Barrios Bernal, Pedro & Yamamoto-Ramos, Masao & Rosell, Rafael. (2019). Effect of Metformin Plus Tyrosine Kinase Inhibitors Compared With Tyrosine Kinase Inhibitors Alone in Patients With Epidermal Growth Factor Receptor–Mutated Lung Adenocarcinoma: A Phase 2 Randomized Clinical Trial. JAMA Oncology. 5. e192553. 10.1001/jamaoncol.2019.2553.
  24. Rodriguez Lara, Vianey & Ramírez-Tirado, Laura-Alejandra & Barron, Feliciano & Zatarain-Barrón, Zyanya & Flores, Diana & Arrieta, Oscar. (2019). Characteristics of non-small cell lung cancer: Differences by sex and hormonal status in a Mexican population. Salud publica de Mexico. 61. 265-275. 10.21149/10094.
  25. Ramírez-Tirado, Laura-Alejandra & Uribe-Ortiz, Cesar & Arrieta, Oscar & Tirado-Gómez, Laura. (2019). Lung cancer mortality and municipal marginalization in Mexico, 1998-2016. Salud publica de Mexico. 61. 249-256. 10.21149/10083.
  26. Rojas, Leonardo & Cardona, Andrés & Trejo‐Rosales, Rogelio & Zatarain‐Barrón, Zyanya & Ramírez-Tirado, Laura-Alejandra & Ruiz Patiño, Alejandro & Campos-Gomez, Saul & Corrales, Luis & Oblitas, George & Bacon, Ludwing & Martin, Claudio & Lima, Vladmir & Freitas, Helano & Mas, Luis & Vargas, Carlos & Carranza, Hernan & Otero, Jorge & Pérez, María & González, Lisde & Arrieta, Oscar. (2019). Supplementary Material 2.
  27. Rojas, Leonardo & Cardona, Andrés & Trejo‐Rosales, Rogelio & Zatarain‐Barrón, Zyanya & Ramírez-Tirado, Laura-Alejandra & Ruiz Patiño, Alejandro & Campos-Gomez, Saul & Corrales, Luis & Oblitas, George & Bacon, Ludwing & Martin, Claudio & Lima, Vladmir & Freitas, Helano & Mas, Luis & Vargas, Carlos & Carranza, Hernan & Otero, Jorge & Pérez, María & González, Lisde & Arrieta, Oscar. (2019). Supplementary Material 3.  
  28. Rojas, Leonardo & Cardona, Andrés & Trejo‐Rosales, Rogelio & Zatarain‐Barrón, Zyanya & Ramírez-Tirado, Laura-Alejandra & Ruiz Patiño, Alejandro & Campos-Gomez, Saul & Corrales, Luis & Oblitas, George & Bacon, Ludwing & Martin, Claudio & Lima, Vladmir & Freitas, Helano & Mas, Luis & Vargas, Carlos & Carranza, Hernan & Otero, Jorge & Pérez, María & González, Lisde & Arrieta, Oscar. (2019). Supplementary Material 1.
  29. Rojas, Leonardo & Cardona, Andrés & Trejo‐Rosales, Rogelio & Zatarain‐Barrón, Zyanya & Ramírez-Tirado, Laura-Alejandra & Ruiz Patiño, Alejandro & Campos-Gomez, Saul & Corrales, Luis & Oblitas, George & Bacon, Ludwing & Martin, Claudio & Lima, Vladmir & Freitas, Helano & Mas, Luis & Vargas, Carlos & Carranza, Hernan & Otero, Jorge & Pérez, María & González, Lisde & Arrieta, Oscar. (2019). Characteristics and long‐term outcomes of advanced pleural mesothelioma in Latin America (MeSO‐CLICaP). Thoracic Cancer. 10. 10.1111/1759-7714.12967.
  30. Arrieta, Oscar & Barron, Feliciano & Magos, Federico & Corona-Cruz, Jose & Blake, Monika & Ramírez-Tirado, Laura-Alejandra & Zatarain-Barrón, Zyanya & Cardona, Andrés & Garcia-Perez, Francisco & Arén Frontera, Osvaldo & Garza, Jaime. (2019). Radical consolidative treatment provides a clinical benefit and long-term survival in patients with synchronous oligometastatic non-small cell lung cancer: A phase II study. Lung Cancer. 130. 10.1016/j.lungcan.2019.02.006.
  31. Arrieta, Oscar & Cardona, Andrés F & Bramuglia, Guillermo & Cruz Rico, Graciela & Corrales, Luis & Martin, Claudio & Imaz-Olguín, Victoria & Castillo-Fernandez, Omar & Cuello, Mauricio & Rojas-Bilbao, Érica & Casas, Gabriel & Fernández, Cristina & Arén Frontera, Osvaldo & Denninghoff, Valeria & Recondo, Gonzalo & Avilés-Salas, Alejandro & Mas, Luis & Oblitas, George & Rojas, Leonardo & Raez, Luis E. (2018). Molecular Epidemiology of ALK Rearrangements in Advanced Lung Adenocarcinoma in Latin America. Oncology. 96. 1-10. 10.1159/000493733.
  32. Salazar, Javier & Ramírez-Tirado, Laura-Alejandra & Contreras, Nora & Arrieta, Oscar & Gallardo, Dolores & Maus, Gabriela. (2018). Leukocytosis, but Not Thrombocytosis, May Constitute a Prothrombotic Pathway in Women with Ovarian Cancer: A Cohort Study. Blood. 132. 10.1182/blood-2018-99-120193.
  33. Corona-Cruz, Jose & Castillo-Castañon, A & Deneken, Zuratzi & Ramírez-Tirado, Laura-Alejandra & Gonzalez-Enciso, A & Gallardo-Rincón, Dolores & Jiménez-Fuentes, Edgardo & Arrieta, Oscar. (2018). Prolonged survival (SV) associated with pulmonary metastasectomy (PM) for carcinomas of the cervix (CC). Annals of Oncology. 29. 10.1093/annonc/mdy285.192.
  34. Turcott, Jenny & Oñate-Ocaña, Luis & Soca Chafre, Giovanny & Ramírez-Tirado, Laura-Alejandra & Flores, Diana & Zatarain-Barrón, Zyanya & Arrieta, Oscar. (2018). FAACT-Anorexia Cachexia Scale: Cutoff Value for Anorexia Diagnosis in Advanced Non-Small Cell Lung Cancer Patients. Nutrition and Cancer. 71. 1-9. 10.1080/01635581.2018.1506488.
  35. Arrieta, Oscar & Lozano-Ruiz, Francisco & Blake, M. & Zatarain-Barrón, Z. & Ramírez-Tirado, Laura-Alejandra & Padilla, M. & Maldonado, F. & Corona-Cruz, Jose. (2018). P2.06-02 Feasibility of Intensity Modulated Radiotherapy After Pleurectomy/Decortication for Malignant Pleural Mesothelioma Patients. Journal of Thoracic Oncology. 13. S743. 10.1016/j.jtho.2018.08.1257.
  36. Gonzalez-Ling, A. & Magos, Federico & Padilla, M. & Arguelles, Manuel & Ramírez-Tirado, Laura-Alejandra & Zatarain-Barrón, Z. & Barron, Feliciano & Flores, Diana & Cardona, A. & Arrieta, Oscar. (2018). P1.01-03 Effect of Prophylactic Cranial Irradiation on Cognitive Function and QoL in NSCLC Patients at High Risk of Brain Metastases. Journal of Thoracic Oncology. 13. S458-S459. 10.1016/j.jtho.2018.08.559.
  37. Rodriguez Lara, Vianey & Ramírez-Tirado, Laura-Alejandra & Flores, Diana & Barron, Feliciano & Zatarain, Lucia & Arrieta, Oscar. (2018). P2.01-11 Characteristics of Non-Small Cell Lung Cancer: Differences by Sex and Hormonal Status in a Hispanic Population. Journal of Thoracic Oncology. 13. S668-S669. 10.1016/j.jtho.2018.08.1065.
  38. Cruz Rico, Graciela & Popa, Xitlally & Avilés-Salas, Alejandro & Flores-Vélez, K.Y. & Cardona, Andrés & Ramírez-Tirado, Laura-Alejandra & Vergara, Edgar & Barron, Feliciano & Arrieta, Oscar. (2018). P2.04-01 Associations Histological Subtype of Lung Adenocarcinoma and Programmed Death Ligand 1 (PD-L1) Expression in Tumor Cells.. Journal of Thoracic Oncology. 13. S730. 10.1016/j.jtho.2018.08.1225.
  39. Muñiz-Hernandez, Sae & Ramírez-Tirado, Laura-Alejandra & Maldonado, Altagracia & Hernández-Cueto, Daniel & Baay-Guzman, Guillermina & Huerta-Yepez, Sara & Arrieta, Oscar. (2018). P2.06-26 Ribonucleotide Reductase Subunit M1 but not M2 is Associated to Better PFS in Patients with Advanced Stage Mesothelioma. Journal of Thoracic Oncology. 13. S752-S753. 10.1016/j.jtho.2018.08.1281.
  40. Arrieta, Oscar & Magos, Federico & Ramírez-Tirado, Laura-Alejandra & Barron, Feliciano & Campos-Salgado, Yelitza & Blake, M. & Cardona, Andrés & Garza, Jaime. (2018). MA08.02 Prophylactic Cranial Irradiation Reduces the Risk of Brain Metastases in High-Risk Lung Cancer Patients: EGFR and ALK Mutations. Journal of Thoracic Oncology. 13. S382. 10.1016/j.jtho.2018.08.377.
  41. Barron, Feliciano & Zatarain, Lucia & Ramírez-Tirado, Laura-Alejandra & Padilla, Miguel-Ángel & Corona-Cruz, Jose & Cardona, Andrés & Arguelles, Manuel & Magos, Federico & Blake, M. & Jiménez-Fuentes, Edgardo & Arén Frontera, Osvaldo & Arrieta, Oscar. (2018). MA25.10 Complete Response by PET-CT After Radical Treatment in Oligometastatic Non-Small Cell Lung Cancer Predicts Longer Survival. Journal of Thoracic Oncology. 13. S449. 10.1016/j.jtho.2018.08.536.
  42. Arrieta, Oscar & Cruz Rico, Graciela & Avilés-Salas, Alejandro & Popa, Xitlally & Flores-Vélez, K.Y. & Ramírez-Tirado, Laura-Alejandra & Vergara, Edgar & Barron, Feliciano. (2018). P03 Histological Subtype of Lung Adenocarcinoma and Programmed Death Ligand 1 (PD-L1) Expression in Tumor Cells. Journal of Thoracic Oncology. 13. S162. 10.1016/j.jtho.2018.07.042.
  43. Muñiz-Hernández, Saé & Ramírez-Tirado, Laura-Alejandra & Arrieta, Oscar. (2018). Abstract 5439: Study of polymorphisms in stra6 in Mexican population with non-small cell lung cancer. Cancer Research. 78. 5439-5439. 10.1158/1538-7445.AM2018-5439.
  44. Corona-Cruz, Jose & López-Saucedo, Raúl & Ramírez-Tirado, Laura-Alejandra & Perez Montiel, Delia & Luna, J. & Jiménez-Fuentes, Edgardo & Arrieta, Oscar. (2018). Extended resections of large thymomas. Journal of Thoracic Disease. 10. 10.21037/jtd.2018.05.101.
  45. Arrieta, Oscar & Barron, Feliciano & Padilla, Miguel-Ángel & Ramírez-Tirado, Laura-Alejandra & Flores, Diana & Cruz Rico, Graciela & Arguelles, Manuel & Cardona, Andres. (2018). Combination of metformin plus TKI vs. TKI alone in EGFR(+) LUNG adenocarcinoma: A randomized phase II study.
  46. Corona-Cruz, Jose & Salvador, M. & Ramírez-Tirado, Laura-Alejandra & Luna, J. & Alvarez-Avitia, Miguel & Jiménez-Ríos, Miguel & López-Saucedo, Raúl & Jiménez-Fuentes, Edgardo & Arrieta, Oscar. (2018). Long survival (SV) for metastatic renal cell cancer (mRCC) after cytoreductive nephrectomy (CN) plus lung metastasectomy (LM) without targeted therapy (TT).
  47. Arrieta, Oscar & Barron, Feliciano & Padilla, Miguel-Ángel & Ramírez-Tirado, Laura-Alejandra & Flores, Diana & Cruz Rico, Graciela & Arguelles, Manuel & Zorrilla, Andres. (2018). Combination of metformin plus TKI vs. TKI alone in EGFR(+) LUNG adenocarcinoma: A randomized phase II study.. Journal of Clinical Oncology. 36. 9013-9013. 10.1200/JCO.2018.36.15_suppl.9013.
  48. Barron, Feliciano & Cardona, Andrés & Corrales, Luis & Ramírez-Tirado, Laura-Alejandra & Perez, Enrique & Sánchez Dominguez, Gisela & Flores, Diana & Barrón, Zyanya & Arrieta, Oscar. (2018). Characteristics of progression to tyrosine kinase inhibitors predict overall survival in patients with advanced non-small cell lung cancer harboring an EGFR mutation. Journal of Thoracic Disease. 10. 10.21037/jtd.2018.03.106.
  49. Arrieta, Oscar & Garcia-Perez, Francisco & Michel-Tello, David & Ramírez-Tirado, Laura-Alejandra & Pitalua-Cortes, Quetzali & Cruz Rico, Graciela & Macedo-Pérez, Eleazar & Cardona, Andres & Garza, Jaime. (2018). ninte-pet.
  50. Arrieta, Oscar & Ramírez-Tirado, Laura-Alejandra & Michel-Tello, David & Turcott, Jenny & Martinez-Hernandez, J. & Beck-Magaña, A. & Servin, Edgar & Verastegui, Emma & Allende-Pérez, Silvia. (2017). MA 08.10 Favorable Clinical Status Predicts Benefit From Early-Palliative Cares & OS Improvement in NSCLC: A Randomized Clinical Study. Journal of Thoracic Oncology. 12. S1834. 10.1016/j.jtho.2017.09.522.
  51. Barron, Feliciano & Ramírez-Tirado, Laura-Alejandra & Macedo-Pérez, Eleazar & Arroyo-Hernández, Marisol & Flores, Diana & Dorantes, Y. & Magos, Federico & Arrieta, Oscar. (2017). P3.14-012 Risk of Developing Pneumonitis Increases in Patients Receiving Immunotherapy with a History of Lung Irradiation. Journal of Thoracic Oncology. 12. S2335. 10.1016/j.jtho.2017.09.1785.
  52. Macedo-Pérez, Eleazar & Lyra-González, I. & Marroquín-Flores, D. & Cruz Rico, Graciela & Ramírez-Tirado, Laura-Alejandra & Valdez-Rojas, L. & Tabares-Nañez, A. & Gonzales-Nogales, J. & Arrieta, Oscar. (2017). P2.01-049 Long Progression Free Survival and Overall Survival in Advanced NSCLC Patients with EGFR Mutation and Complete Response with TKI Treatment. Journal of Thoracic Oncology. 12. S2088. 10.1016/j.jtho.2017.09.1151.
  53. Martin, Claudio & Cardona, A. & Arrieta, Oscar & Castillo-Fernandez, Omar & Oblitas, George & Corrales, Luis & Lupinacci, Lorena & Pérez, M.A. & Rojas, Leonardo & Gonzalez, Leslye & Chirinos, L. & Ortiz, Carlos & Lema, M. & Vargas, Carlos & Puparelli, Carmen & Carranza, Hernan & Otero, Jorge & Ramírez-Tirado, Laura-Alejandra. (2017). P1.01-019 ALK+ Non-Small Cell Lung Cancer Treated with First Line Crizotinib: Patient Characteristics, Treatment Patterns, and Survival. Journal of Thoracic Oncology. 12. S1899-S1900. 10.1016/j.jtho.2017.09.673.
  54. Turcott, Jenny & Ramírez-Tirado, Laura-Alejandra & Oñate-Ocaña, Luis & Flores, Diana & Zatarain, Lucia & Soca Chafre, Giovanny & Arrieta, Oscar. (2017). P2.01-070 FAACT- Anorexia Cachexia Scale: Cut-Off Value for the Anorexia Diagnosis in NSCLC Patients. Journal of Thoracic Oncology. 12. S2098. 10.1016/j.jtho.2017.09.1177. Barron, Feliciano & Ramírez-Tirado, Laura-Alejandra & MacedoPérez, O. & Arroyo-Hernández, Marisol & Flores, Diana & Dorantes, Y. & Maldonado, F. & Arrieta, Oscar. (2017). RISK OF DEVELOPING PNEUMONITIS INCREASES IN PATIENTS RECEIVING IMMUNOTHERAPY WITH A HISTORY OF LUNG IRRADIATION.
  55. Arrieta, Oscar & Ramírez-Tirado, Laura-Alejandra & Michel-Tello, David & Turcott, Jenny & Martinez-Hernandez, J & Beck-Magaña, A & Servin, Edgar & Verastegui, Emma & Allende-Pérez, Silvia. (2017). FAVORABLE CLINICAL STATUS PREDICTS BENEFIT FROM EARLY-PALLIATIVE CARES & OS IMPROVEMENT IN NSCLC: A RANDOMIZED CLINICAL STUDY.
  56. Arrieta, Oscar & Garcia-Perez, Francisco & Michel-Tello, David & Ramírez-Tirado, Laura-Alejandra & Pitalua-Cortes, Quetzali & Cruz Rico, Graciela & Macedo-Pérez, Eleazar & Cardona, Andres & Garza, Jaime. (2017). Response assessment of (68)Ga-DOTA-E-[c(RGDfK)]2 PET/CT for lung adenocarcinoma patients treated with nintedanib plus docetaxel. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 59. 10.2967/jnumed.117.192393.
  57. Tirado, Laura & Ramírez-Tirado, Laura-Alejandra & Arrieta, Oscar. (2017). P1.01-052 Lung Cancer Mortality in Mexico, 1990-2014. Journal of Thoracic Oncology. 12. S481-S482. 10.1016/j.jtho.2016.11.576.
  58. Ramírez-Tirado, Laura-Alejandra & Martínez-Hernández, Jorge-Negueb & Caballe-Perez, Enrique & Cardona, Andrés & Arrieta, Oscar. (2017). P2.03b-025 Mutation Profile and Histology Subtype According to IASLC/ERS/ATC as Risk Factors for Brain Metastases in Lung Adenocarcinoma. Journal of Thoracic Oncology. 12. S949. 10.1016/j.jtho.2016.11.1306.
  59. Arrieta, Oscar & Caballe-Perez, Enrique & Ramírez-Tirado, Laura-Alejandra & Mejía-López, Alberto & Cerda, Monika & Flores, Diana & Macedo-Pérez, Eleazar & Cardona-Zorrilla, Andres-Felipe & Garza, Jaime. (2017). P2.03b-003 Mutation Profile & Histology According to ERS/ATC/IASCL Associated with IPFS to WBI in BM Patients with Recent Adenocarcinoma Lung Cancer. Journal of Thoracic Oncology. 12. S934. 10.1016/j.jtho.2016.11.1284.
  60. Arrieta, Oscar & Garcia-Perez, Francisco & Michel-Tello, David & Ramírez-Tirado, Laura-Alejandra & Lee-Cervantes, Denisse & Pitalua-Cortes, Quetzali & Macedo-Pérez, Eleazar & Cruz Rico, Graciela. (2017). P2.03b-088 PET-CT with 68Ga-RGD as Biomarker of Response to Nintedanib plus Docetaxel as Second Line Therapy in NSCLC. Journal of Thoracic Oncology. 12. S989-S990. 10.1016/j.jtho.2016.11.1370.
  61. Lee-Cervantes, Denisse & Cruz Rico, Graciela & Michel-Tello, David & Ramírez-Tirado, Laura-Alejandra & Amieva-Rivera, Eduardo & Macedo-Pérez, Eleazar & Flores, Diana & Cardona, Andrés & Arrieta, Oscar. (2017). P2.03b-083 Soluble Angiogenic Factors as Predictive Biomarkers of Response to Docetaxel plus Nintedanib as Second Line Therapy in NSCLC. Journal of Thoracic Oncology. 12. S986. 10.1016/j.jtho.2016.11.1365.
  62. Barron, Feliciano & Ramírez-Tirado, Laura-Alejandra & Caballe-Perez, Enrique & Sánchez Dominguez, Gisela & Cardona, Andrés & Arrieta, Oscar. (2017). P3.02b-125 Failure to Tyrosine Kinase Inhibitors and Patterns of Progression in Patients with Advanced Non-Small Cell Lung Cancer. Journal of Thoracic Oncology. 12. S1269-S1270. 10.1016/j.jtho.2016.11.1793.
  63. Barron, Feliciano & Ramírez-Tirado, Laura-Alejandra & Caballe-Perez, Enrique & Sánchez Dominguez, Gisela & Cardona, Andrés & Arrieta, Oscar. (2016). WCLC2016-Abstract-Book vF-WEB revNov17-1 669.
  64. Ramírez-Tirado, Laura-Alejandra & Martínez-Hernández, Jorge-Negueb & Caballe-Perez, Enrique & Cardona, Andrés & Arrieta, Oscar. (2016). MUTATION PROFILE AND HISTOLOGY SUBTYPE ACCORDING TO IASLC/ERS/ATC AS RISK FACTORS FOR BRAIN METASTASES IN LUNG ADENOCARCINOMA.
  65. Barron, Feliciano & Ramírez-Tirado, Laura-Alejandra & Caballe-Perez, Enrique & Sánchez Dominguez, Gisela & Cardona, Andrés & Arrieta, Oscar. (2016). Failure to Tyrosine Kinase Inhibitors and Patterns of Progression in Patients with Advanced Non-Small Cell Lung Cancer.
  66. Arrieta, Oscar & Caballe-Perez, Enrique & Ramírez-Tirado, Laura-Alejandra & Mejía-López, Alberto & Cerda, Monika & Flores, Diana & Macedo-Pérez, Eleazar & Cardona-Zorrilla, Andres-Felipe & Garza, Jaime. (2016). MUTATION PROFILE & HISTOLOGY ACCORDING TO ERS/ ATC/IASCL ASSOCIATED WITH IPFS TO WBI IN BM PATIENTS WITH RECENT ADENOCARCINOMA LUNG CANCER.
  67. Lee-Cervantes, Denisse & Cruz Rico, Graciela & Michel-Tello, David & Ramírez-Tirado, Laura-Alejandra & Amieva-Rivera, Eduardo & Macedo-Pérez, Eleazar & Flores, Diana & Cardona, Andrés & Arrieta, Oscar. (2016). SOLUBLE ANGIOGENIC FACTORS AS PREDICTIVE BIOMARKERS OF RESPONSE TO DOCETAXEL PLUS NINTEDANIB AS SECOND LINE THERAPY IN NSCLC.
  68. Arrieta, Oscar & Carmona Gonzalez, Carlos & Ramírez-Tirado, Laura-Alejandra & Flores, Diana & Macedo-Pérez, Eleazar & Martínez-Hernández, Jorge-Negueb & Corona-Cruz, Jose & Cardona, Andrés & Garza, Jaime. (2016). Survival of Patients with Advanced Non-Small Cell Lung Cancer Enrolled in Clinical Trials. Oncology. 91. 10.1159/000447404.
  69. Muñiz-Hernandez, Sae & Huerta-Yepez, Sara & Hernández-Pedro, Norma & Ramírez-Tirado, Laura-Alejandra & Avilés-Salas, Alejandro & Maldonado, Altagracia & Hernández-Cueto, Daniel & Baay-Guzman, Guillermina & Arrieta, Oscar. (2016). Association between nuclear expression of retinoic acid receptor alpha and beta and clinicopathological features and prognosis of advanced non-small cell lung cancer. International Journal of Clinical Oncology. 21. 10.1007/s10147-016-1002-0.
  70. Arrieta, Oscar & Caballe-Perez, Enrique & Ramírez-Tirado, Laura-Alejandra & Mejia-Perez, Alberto & Blake-Cerda, Monika & Flores, Diana & Macedo-Pérez, Eleazar & Zorrilla, Andres & Garza, Jaime. (2016). Association of response to whole-brain irradiation of brain metastases with molecular profile in non-small cell lung cancer. Journal of Clinical Oncology. 34. 10.1200/JCO.2016.34.15_suppl.9096.
  71. Arrieta, Oscar & Cruz Rico, Graciela & Soto-Perez-de-Celis, Enrique & Ramírez-Tirado, Laura-Alejandra & Perez, Enrique & Martínez-Alvarez, Jorge & Soca Chafre, Giovanny & Macedo-Pérez, Eleazar & Vega, Horacio. (2016). Reduction in Hepatocyte Growth Factor Serum Levels is Associated with Improved Prognosis in Advanced Lung Adenocarcinoma Patients Treated with Afatinib: a Phase II Trial. Targeted Oncology. 11. 10.1007/s11523-016-0425-x.
  72. Avilés-Salas, Alejandro & Muñiz-Hernandez, Sae & Maldonado-Martinez, Hector & Chanona-Vilchis, Jose & Ramírez-Tirado, Laura-Alejandra & Hernández-Pedro, Norma & Dorantes-Heredia, Rita & Ruiz-Morales, Jose & Motola-Kuba, Daniel & Arrieta, Oscar. (2016). Reproducibility of the EGFR Immunohistochemistry Scores for Tumor Samples from Patients with Advanced Non-Small Cell Lung Cancer. Oncology letters. 13. 912-920. 10.3892/ol.2016.5512.
  73. Arrieta, Oscar & Cruz Rico, Graciela & Ramírez-Tirado, Laura-Alejandra & Negueb, Jorge & Caballé-Pérez, Enrique & Martínez-Alvarez, Iván & Socca-Chafre, Giovanni & Vega, Horacio. (2015). MINI16.11 Plasma HGF Reduction Is Associated with Better Prognosis in EGFR Positive Advanced Lung Adenocarcinoma Patients Treated with Afatinib.
  74. Castillo, María & Ramírez-Tirado, Laura-Alejandra & Báez-Saldaña, Renata & PeñaCuriel, Omar & Macedo-Pérez, Eleazar & Saco-Chafre, Giovanny & Arrieta, Oscar. (2015). ORAL30.07 Different Mutation Profiles and Clinical Characteristics Among Hispanic Patients with NSCLC Could Explain The “Hispanic Paradox”.
  75. Barrera, Lourdes & Arrieta, Oscar & Morales-Flores, Renato & Garcia-Vicente, Angeles & Servin, Edgar & Salinas-Parra, Fernanda & Ramírez-Tirado, Laura-Alejandra. (2015). MINI02.03 Overexpression of CD47, Decrease of apoptosis and Phagocytosis of Neutrophils in Advanced Non-Small Cell Lung Cancer Patients. J Thoracic Oncol. 10.
  76. Arrieta, Oscar & Anaya, Pablo & Morales Oyarvide, Vicente & Ramírez-Tirado, Laura-Alejandra & Polanco, Ana. (2015). Cost-effectiveness analysis of EGFR mutation testing in patients with non-small cell lung cancer (NSCLC) with gefitinib or carboplatin–paclitaxel. The European Journal of Health Economics. 17. 10.1007/s10198-015-0726-5.
  77. Arrieta, Oscar & Ramírez-Tirado, Laura-Alejandra & Báez-Saldaña, Renata & Peña Curiel, Omar & Soca Chafre, Giovanny & Macedo-Pérez, Eleazar. (2015). Different mutation profiles and clinical characteristics among Hispanic patients with non-small cell lung cancer could explain the “Hispanic paradox”. Lung Cancer. 90. 10.1016/j.lungcan.2015.08.010.
  78. Cruz Rico, Graciela & Avilés-Salas, Alejandro & Segura-Gonzalez, Manuel & Espinosa Garcia, Ana Maria & Ramírez-Tirado, Laura-Alejandra & Morales-Oyarvidez, Vicente & Rojas-Marin, Carlos & Cardona, Andres-Felipe & Arrieta, Oscar. (2015). Diagnosis of EML4 – ALK Translocation with FISH, Immunohistochemistry, and Real-time Polymerase Chain Reaction in Patients with Non-Small Cell Lung Cancer. American Journal of Clinical Oncology. 10.1097/COC.0000000000000213.
  79. Arrieta, Oscar & de la Torre-Vallejo, Martha & macias, Diego & Orta, David & Turcott, Jenny & Macedo-Pérez, Eleazar & Sanchez-lara, Karla & Ramírez-Tirado, Laura-Alejandra & Baracos, Vickie. (2015). Nutritional Status, Body Surface, and Low Lean Body Mass/Body Mass Index Are Related to Dose Reduction and Severe Gastrointestinal Toxicity Induced by Afatinib in Patients With Non-Small Cell Lung Cancer. The Oncologist. 10.1634/theoncologist.2015-0058.
  80. Barrera, Lourdes & Arrieta, Oscar & Servin, Edgar & Ramírez-Tirado, Laura-Alejandra & Bañales-Mendez, J.L. & Salinas-Parra, F.. (2014). 197PDATA MINING CYTOKINES PROFILE FOR PROGNOSIS IN ADVANCED NON-SMALL CELL LUNG CANCER. Japanese Society of Medical Oncology. 25. iv67-iv68. 10.1093/annonc/mdu326.31.
  81. Ramírez-Tirado, Laura-Alejandra & Tirado-Gómez, Laura & Lopez-Cervantes, Malaquías. (2014). Desigualdad en intervenciones de atención primaria para el cuidado de la salud maternoinfantil en México. Revista Panamericana de Salud Pública. 35. 235-241. 
Laura Alejandra Ramirez Tirado, MD, MSc.

Alexandria Reese, BS

MPH Student

Alex's publications explore how sex, race, and lifestyle factors influence Alzheimer's biomarkers and brain health.
  1. Shaaban, C. & Reese, Alexandria & Royse, Sarah & Snitz, Beth & Karikari, Thomas & Hengenius, James & Huppert, Theodore & Roush, Rebecca & Cisneros, Geraldine & Potopenko, Katey & Cohen, Annie. (2025). Intersections of sex and racialization on ATV(N) biomarkers. Alzheimer’s & Dementia. 20. 10.1002/alz.087089. 
  2. Fan, Erica & Royse, Sarah & Reese, Alexandria & Karikari, Thomas & Pascoal, Tharick & Shaaban, C. & Villemagne, Victor & Cohen, Ann. (2024). NEIGHBORHOOD DISADVANTAGE AND THE ASSOCIATION OF PLASMA BIOMARKERS WITH COGNITION IN A COHORT OF DIVERSE ADULTS. Innovation in Aging. 8. 462-463. 10.1093/geroni/igae098.1504. 
  3. Lopresti, Brian & Stehouwer, Jeffrey & Reese, Alexandria & Mason, Neale & Royse, Sarah & Narendran, Rajesh & Laymon, Charles & Lopez, Oscar & Cohen, Ann & Mathis, Chester & Villemagne, Victor. (2024). Kinetic modeling of the monoamine oxidase-B radioligand [18F]SMBT-1 in human brain with positron emission tomography. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 44. 271678X241254679. 10.1177/0271678X241254679. 
  4. Royse, Sarah & Snitz, Beth & Hill, Ashley & Reese, Alexandria & Roush, Rebecca & Kamboh, M & Bertolet, Marianne & Saeed, Anum & Lopresti, Brian & Villemagne, Victor & Lopez, Oscar & Reis, Steven & Cohen, Ann. (2024). Apolipoprotein E and Alzheimer’s disease pathology in African American older adults. Neurobiology of aging. 139. 11-19. 10.1016/j.neurobiolaging.2024.03.005. 
  5. Stradford, Joy & Snitz, Beth & Roush, Rebecca & Reese, Alexandria & Lopresti, Brian & Cisneros, Geraldine & Potopenko, Katey & Lopez, Oscar & Cohen, Ann & Pa, Judy. (2023). Race, inflammation, and amyloid deposition in Black/African American and Non‐Hispanic White older adults. Alzheimer’s & Dementia. 19. 10.1002/alz.078582. 
  6. Royse, Sarah & Saeed, Anum & Reese, Alexandria & Lopresti, Brian & Snitz, Beth & Villemagne, Victor & Nadkarni, Neelesh & Reis, Steven & Lopez, Oscar & Cohen, Ann. (2023). Associations of mid‐life cardiovascular function with late‐life Alzheimer’s disease pathology burden in the Heart SCORE study. Alzheimer’s & Dementia. 19. 10.1002/alz.078247. 
  7. Mukundan, Aishwarya & Rosso, Andrea & Cisneros, Geraldine & Huppert, Theodore & Laymon, Charles & Lopresti, Brian & Potopenko, Katey & Reese, Alexandria & Roush, Rebecca & Snitz, Beth & Cohen, Ann & Shaaban, C.. (2023). Race, Purpose and Meaning of Life, and Markers of Brain Health for Alzheimer’s Disease. Alzheimer’s & Dementia. 19. 10.1002/alz.075116.
  8. Royse, Sarah & Snitz, Beth & Hengenius, James & Huppert, Theodore & Roush, Rebecca & Ehrenkranz, Rebecca & Wilson, James & Bertolet, Marianne & Reese, Alexandria & Cisneros, Geraldine & Potopenko, Katey & Cohen, Ann & Shaaban, C.. (2023). Unhealthy white matter connectivity, cognition, and racialization in older adults. Alzheimer’s & Dementia. 20. 10.1002/alz.13494. 
Yixiao (Tracy) Song

Yixiao Song, MS

PhD Student

Yixiao studies how apathy in older adults may be influenced by nigrostriatal dopaminergic transmission, while mid-life adherence to the DASH diet could reduce late-life cognitive complaints in women.
  1. Song Y, Cawthon P, Butters M, Chahine L, Rosano C. THE CONTRIBUTION OF NIGROSTRIATAL DOPAMINERGIC TRANSMISSION ON APATHY IN OLDER ADULTS. Innov Aging. 2024 Dec 31;8(Suppl 1):1041. doi: 10.1093/geroni/igae098.3349. PMCID: PMC11692989.
  2. Song Y, Wu F, Sharma S, Clendenen TV, India-Aldana S, Afanasyeva Y, Gu Y, Koenig KL, Zeleniuch-Jacquotte A, Chen Y. Mid-life adherence to the Dietary Approaches to Stop Hypertension (DASH) diet and late-life subjective cognitive complaints in women. Alzheimers Dement. 2024 Feb;20(2):1076-1088. doi: 10.1002/alz.13468. Epub 2023 Oct 20. PMID: 37861080; PMCID: PMC10917042.
  3. Li, X., Deng, S., Pang, X., Song, Y., Luo, S., Jin, L., & Pan, Y. (2019). LncRNA NEAT1 Silenced miR-133b Promotes Migration and Invasion of Breast Cancer Cells. International Journal of Molecular Sciences, 20(15), 3616. https://doi.org/10.3390/ijms20153616  
Daniel Willie-Permor, MD, MPH, CPH

Daniel Willie-Permor, MD, MPH, CPH

PhD Student

Daniel's publications explore the effects of preoperative conditions, access to care, and surgical techniques on vascular surgery outcomes.
    1. Willie-Permor, Daniel & Straus, Sabrina & Sendek, Gabriela & Moghaddam, Marjan & Zarrintan, Sina & Ross, Elsie & Malas, Mahmoud. (2024). Medicare Patients With Symptomatic Carotid Disease Requiring Carotid Revascularization Are Likely to Have Delayed Access: An Analysis Of A Multi-Center Surgical Data. Annals of Vascular Surgery. 112. 10.1016/j.avsg.2024.11.096. 
    2. Straus, Sabrina & Vootukuru, Nishita & Willie-Permor, Daniel & Elsayed, Nadin & Ross, Elsie & Malas, Mahmoud. (2024). The Effect of Preoperative Smoking Status on Carotid Endarterectomy Outcomes in Asymptomatic Patients. Journal of Vascular Surgery. 81. 10.1016/j.jvs.2024.11.031. 
    3. Veranyan, Narek & Willie-Permor, Daniel & Zarrintan, Sina & Malas, Mahmoud. (2024). Clinical Outcomes of Celiac Artery Coverage vs Preservation During Thoracic Endovascular Aortic Repair. Journal of Vascular Surgery. 80. 10.1016/j.jvs.2024.07.006.
    4. Patel, Rohini & Willie-Permor, Daniel & Fan, Austin & Zarrintan, Sina & Malas, Mahmoud. (2024). 30-Day Risk Score for Mortality and Stroke in Patients with Carotid Artery Stenosis Using Artificial Intelligence Based Carotid Plaque Morphology. Annals of Vascular Surgery. 109. 10.1016/j.avsg.2024.05.016.
    5. Straus, Sabrina & Barodi, Batol & Zarrintan, Sina & Willie-Permor, Daniel & Vootukuru, Nishita & Malas, Mahmoud. (2024). A Contemporary Evaluation of the Centers for Medicare and Medicaid Services High-Risk Indicators for Carotid Endarterectomy. Annals of surgery. 280. 10.1097/SLA.0000000000006397.
    6. Willie-Permor, Daniel & Straus, Sabrina & Elsayed, Nadin & Malas, Mahmoud. (2024). Mid-term Outcomes Of Transcarotid Artery Revascularization vs Carotid Endarterectomy Among Standard Risk Patients. Journal of Vascular Surgery. 79. e193-e194. 10.1016/j.jvs.2024.03.248.
    7. Straus, Sabrina & Vootukuru, Nishita & Willie-Permor, Daniel & Elsayed, Nadin & Ross, Elsie & Malas, Mahmoud. (2024). The Effect Of Smoking Status On Short And Mid-Term Outcomes Of Asymptomatic Patients Undergoing Carotid Endarterectomy: Analysis Of National Multi-Institutional Data. Journal of Vascular Surgery. 79. e334-e335. 10.1016/j.jvs.2024.03.434.
    8. Straus, Sabrina & Barodi, Batol & Willie-Permor, Daniel & Vootukuru, Nishita & Malas, Mahmoud. (2024). Re-Evaluating The Centers For Medicare And Medicaid Services (CMS) High-Risk Criteria For Carotid Artery Revascularization. Journal of Vascular Surgery. 79. e335-e336. 10.1016/j.jvs.2024.03.435.
    9. Farah, Marc & Moghaddam, Marjan & Zarrintan, Sina & Willie-Permor, Daniel & Schermerhorn, Marc & Malas, Mahmoud. (2024). The Effect of Controlled versus Uncontrolled Hypertension on Outcomes of Carotid Revascularization Procedures. Journal of vascular surgery. 80. 10.1016/j.jvs.2024.05.021.
    10. Ramachandran, Mokhshan & Unkart, Jonathan & Willie-Permor, Daniel & Hamouda, Mohammed & Elsayed, Nadin & Malas, Mahmoud. (2024). The Obesity Paradox Exists for Perioperative Complications and Mortality Following Lower Extremity Arterial Bypass Surgery. Journal of Vascular Surgery. 80. 10.1016/j.jvs.2024.04.044.
    11. Willie-Permor, Daniel & Real, Marcos & Zarrintan, Sina & Gaffey, Ann & Malas, Mahmoud. (2023). Perioperative Blood Transfusion Is Associated With Worse 30-Day Mortality And Complications After Thoracic Endovascular Aortic Repair. Annals of Vascular Surgery. 101. 10.1016/j.avsg.2023.10.030.
    12. Chow, Christopher & Zarrintan, Sina & Willie-Permor, Daniel & Elsayed, Nadin & Baril, R.D.T. & Malas, Mahmoud. (2023). Postoperative Outcomes and One-Year Mortality of Patients on Chronic Anticoagulation Medications Undergoing Infrainguinal Bypass. Annals of Vascular Surgery. 99. 10.1016/j.avsg.2023.07.110.
    13. Willie-Permor, Daniel & Rahgozar, Shima & Zarrintan, Sina & Alsaigh, Tom & Gaffey, Ann & Malas, Mahmoud. (2023). Patients With Prior Exposure To A Combination of Statins & Angiotensin Converting Enzyme Inhibitors (ACE-Is)/Angiotensin receptor blockers(ARBs) Have Better Outcomes After Carotid Revascularization Than Patients With Prior Exposure To Statins Alone: A Multi-Center Analysis. Annals of Vascular Surgery. 100. 10.1016/j.avsg.2023.08.036.
    14. Willie-Permor, Daniel & Straus, Sabrina & Rahgozar, Shima & Wellington, Hannah & Shalhub, Sherene & Malas, Mahmoud. (2023). Contemporary Outcomes of Thoracic Endovascular Aortic Repair in Patients With Connective Tissue Disorders: A Multi-Centre National Study. Journal of Vascular Surgery. 78. e62-e63. 10.1016/j.jvs.2023.06.098.
    15. Straus, Sabrina & Moghaddam, Marjan & Zarrintan, Sina & Willie-Permor, Daniel & Jagadeesh, Vasan & Malas, Mahmoud. (2023). Modality-Specific Outcomes of Patients Undergoing Carotid Revascularization in the Setting of Recent Myocardial Infarction. Journal of Vascular Surgery. 79. 10.1016/j.jvs.2023.09.024.
    16. Naazie, Isaac & Willie-Permor, Daniel & Haykal, Tony & Harris, Linda & Hughes, Kakra & Malas, Mahmoud. (2023). Association Between Conduit Type and Outcomes After Open Repair of Popliteal Artery Aneurysms. The Journal of surgical research. 291. 670-676. 10.1016/j.jss.2023.06.021.
    17. Patel, Rohini & Willie-Permor, Daniel & Zarrintan, Sina & Fan, Austin & Malas, Mahmoud. (2023). Using a CT Angiography Artificial Intelligence Carotid Plaque Morphology Model to Predict Stroke. Journal of Vascular Surgery. 77. e278-e279. 10.1016/j.jvs.2023.03.388.
    18. Moacdieh, Munir & Zarrintan, Sina & Willie-Permor, Daniel & Rahgozar, Shima & Malas, Mahmoud. (2023). Open Versus Endovascular Left Subclavian Artery Revascularization Outcomes in Thoracic Endovascular Aortic Repair: A National Study. Journal of Vascular Surgery. 77. e172. 10.1016/j.jvs.2023.03.237.
    19. Straus, Sabrina & Malas, Mahmoud & Zarrintan, Sina & Moghaddam, Marjan & Willie-Permor, Daniel. (2023). Optimal Method of Carotid Revascularization in Patients With Recent Myocardial Infarction. Journal of Vascular Surgery. 77. e135-e136. 10.1016/j.jvs.2023.03.186.
    20. Ramachandran, Mokhshan & Unkart, Jonathan & Willie-Permor, Daniel & Hamouda, Mohammed & Elsayed, Nadin & Malas, Mahmoud. (2023). Paradoxical Associations Exist Between BMI Category and Perioperative Complications Following Lower Extremity Arterial Bypass. Journal of Vascular Surgery. 77. e192-e194. 10.1016/j.jvs.2023.03.263.
    21. Moghaddam, Marjan & Zarrintan, Sina & Willie-Permor, Daniel & Siracuse, Jeffrey & Malas, Mahmoud. (2023). Transcarotid Artery Revascularization Is the Safest Carotid Artery Revascularization Option for Patients With Symptomatic Congestive Heart Failure. Journal of Vascular Surgery. 77. e109. 10.1016/j.jvs.2023.03.174.
    22. Farah, Marc & Moghaddam, Marjan & Zarrintan, Sina & Willie-Permor, Daniel & Schermerhorn, Marc & Malas, Mahmoud. (2023). The Effect of Controlled Versus Uncontrolled Hypertension on Outcomes in Carotid Revascularization Procedures. Journal of Vascular Surgery. 77. e132-e133. 10.1016/j.jvs.2023.03.182.
    23. Zarrintan, Sina & Willie-Permor, Daniel & Patel, Rohini & Malas, Mahmoud. (2023). Covered Endovascular Reconstruction of Aortic Bifurcation Is Comparable to Aortobifemoral Bypass in Midterm Follow-up: A Multi-institutional Study from a Medicare-Linked Database. Journal of Vascular Surgery. 77. e351-e352. 10.1016/j.jvs.2023.03.487.
    24. Zarrintan, Sina & Willie-Permor, Daniel & Patel, Rohini & Alsaigh, Tom & Malas, Mahmoud. (2023). Factors Associated With 1-year Amputation-free Survival Following Lower Extremity Revascularization in Patients with Chronic Limb-threatening Ischemia: An Analysis of VQI-VISION Database. Journal of Vascular Surgery. 77. e196-e197. 10.1016/j.jvs.2023.03.266.
    25. Willie-Permor, Daniel & Sendek, Gabriela & Moghaddam, Marjan & Zarrintan, Sina & Malas, Mahmoud. (2023). Medicare Patients with Symptomatic Carotid Disease Requiring Carotid Revascularization Are Likely to Have Delayed Access: An Analysis of a Multicenter Surgical Data. Journal of Vascular Surgery. 77. e280-e281. 10.1016/j.jvs.2023.03.391.
    26. Ramakrishnan, Ganesh & Willie-Permor, Daniel & Yei, Kevin & Nejim, Besma & Enuma, Zachary & Gasparis, Antonios & Malas, Mahmoud. (2023). Immediate and delayed complications of inferior vena cava filters. European Journal of Vascular and Endovascular Surgery. 65. e60. 10.1016/j.ejvs.2023.04.035.
    27. Patel, Rohini & Cui, Christina & Khan, Maryam Ali & Willie-Permor, Daniel & Malas, Mahmoud. (2023). Cost-Effectiveness Analysis of Open Versus Endovascular Revascularization for Chronic Mesenteric Ischemia. Annals of vascular surgery. 94. 10.1016/j.avsg.2023.02.013.
    28. Patel, Rohini & Willie-Permor, Daniel & Zarrintan, Sina & Elsayed, Nadin & Al-Nouri, Omar & Malas, Mahmoud. (2023). Two-Stage Offers No Advantages Over Single Stage Arteriovenous Creation: An Analysis of Multi-Center National Data. Annals of Vascular Surgery. 96. 10.1016/j.avsg.2023.03.020.
    29. Zarrintan, Sina & Willie-Permor, Daniel & Siracuse, Jeffrey & Barleben, Andrew & Malas, Mahmoud. (2023). Prior Endovascular Intervention Is Not Associated With Unfavorable Outcomes in Infrainguinal Bypass Surgery for Chronic Limb-Threatening Ischemia: A Propensity Score-Matched Analysis of the VQI-Medicare-Linked Database. Journal of Vascular Surgery. 77. e20-e21. 10.1016/j.jvs.2022.11.022.
    30. Ramakrishnan, Ganesh & Willie-Permor, Daniel & Yei, Kevin & Nejim, Besma & Enuma, Zachary & Gasparis, Antonios & Malas, Mahmoud. (2022). Immediate and Delayed Complications of IVC Filters. Journal of Vascular Surgery: Venous and Lymphatic Disorders. 11. 10.1016/j.jvsv.2022.08.011.
    31. Yin, Kanhua & Willie-Permor, Daniel & Zarrintan, Sina & Dakour Aridi, Hanaa & Ramirez, Joel & Iannuzzi, James & Naazie, Isaac & Malas, Mahmoud. (2022). Anemia is Associated with Higher Mortality and Morbidity After Thoracic Endovascular Aortic Repair. Journal of Vascular Surgery. 77. 10.1016/j.jvs.2022.08.037.

       

    Anthony Zomalt

    Jonathan Wang, BSc, PhD

    Postdoctoral Scholar

    Jonathan's papers collectively focus on gravitational wave detection from both supernova remnants and compact binary mergers
    1. Abbott, R & Collaboration, LIGO & Collaboration, Virgo. (2022). Search of the early O3 LIGO data for continuous gravitational waves from the Cassiopeia A and Vela Jr. supernova remnants. Physical Review D. 105.
    2. Wang, Jonathan & Riles, Keith. (2024). Deep search of the full O3 LIGO data for continuous gravitational waves from the Cassiopeia A central compact object. Physical Review D. 110. 10.1103/PhysRevD.110.042006.
    3. Hanna, Claris & Sakon, Shio & Privitera, Stephen & Fernandez, Miguel & Wang, Jonathan & Messick, Cody & Pace, Alex & Cannon, Kipp & Joshi, Prathamesh & Huxford, Rachael & Caudill, Sarah & Chan, Chiwai & Cousins, Bryce & Creighton, Jolien & Ewing, Becca & Fong, Heather & Godwin, Polgap & Magee, Ryan & Wade, Madeline. (2023). Binary tree approach to template placement for searches for gravitational waves from compact binary mergers. Physical Review D. 108. 10.1103/PhysRevD.108.042003.
    Erica Fan

    Erica Fan, MPH

    MD/PhD Student

    Erica's studies focus on the health of older adults, examining the impact of the outdoor environment on falls and the relationship between brain health and mobility confidence. Additionally, other work explores molecular mechanisms of metabolism and community perception of flu and COVID vaccinations.
    1. Fan, Erica & Royse, Sarah & Reese, Alexandria & Karikari, Thomas & Pascoal, Tharick & Shaaban, C. & Villemagne, Victor & Cohen, Ann. (2024). NEIGHBORHOOD DISADVANTAGE AND THE ASSOCIATION OF PLASMA BIOMARKERS WITH COGNITION IN A COHORT OF DIVERSE ADULTS. Innovation in Aging. 8. 462-463. 10.1093/geroni/igae098.1504. 
    2. Shaaban CE, Fan E, Klatt BN, Cohen AD, Snitz BE, Yu Z, Lopresti BJ, Villemagne VL, Klunk WE, Aizenstein HJ, Rosso AL. Brain health correlates of mobility-related confidence. Exp Gerontol. 2022 Jun 15;163:111776. doi: 10.1016/j.exger.2022.111776. Epub 2022 Mar 24. PMID: 35339632; PMCID: PMC9109136. 
    3. Fan L, Sweet DR, Fan EK, Prosdocimo DA, Madera A, Jiang Z, Padmanabhan R, Haldar SM, Vinayachandran V, Jain MK. Transcription factors KLF15 and PPARδ cooperatively orchestrate genome-wide regulation of lipid metabolism in skeletal muscle. J Biol Chem. 2022 Jun;298(6):101926. doi: 10.1016/j.jbc.2022.101926. Epub 2022 Apr 9. PMID: 35413288; PMCID: PMC9190004. 
    4. Murali A, Sojati J, Levochkina M, Pressimone C, Griffith K, Fan E, Dakroub A. A CrossSectional Analysis of Community Perceptions of Flu and COVID-19 Vaccines at Turtle Creek Primary Care Center. Community Health Equity Res Policy. 2024 Jul;44(4):439-451. doi: 10.1177/2752535X231205665. Epub 2023 Oct 14. PMID: 37837451. 
    5. Dunlap PM, Fan EK, Hubbard ZL, VonVille HM, Strotmeyer ES, Rosso AL. Outdoor Environmental Risk Factors for Falls and Fear of Falling: A Systematic Review. Gerontologist. 2025 Feb 19:gnaf078. doi: 10.1093/geront/gnaf078. Epub ahead of print. PMID: 39969174.
    Meredith Phillips, PhD

    Meredith Phillips, PhD

    Postdoctoral Scholar

     

    Meredith's diverse collection of papers decodes how socioeconomic factors, genetics, and awareness influence brain health, Alzheimer’s, and innovative research methods.
      1. Phillips ML, Gianaros P, Rosso A. Estimating the association between three measures of midlife socioeconomic status and brain structure. 
      2. Venkatesh S, Willie-Permor D, Ramirez L, Phillips ML, Rosano C, Rosso A, Shaaban B. HEARD RIGHT: Redefining Representation and Equity in ADRD Research. 
      3. Beidelman, Erika & Chakraborty, Rishika & Jock, Janet & Kabudula, Chodziwadziwa & Phillips, Meredith & Kahn, Kathleen & Eyal, Katherine & Bassil, Darina & Berkman, Lisa & Kobayashi, Lindsay & Rosenberg, Molly. (2024). Impact of the South African Child Support Grant on memory decline and dementia probability in rural and low-income mothers, 2014-2021. Social Science & Medicine. 358. 117217. 10.1016/j.socscimed.2024.117217. 
      4. Chakraborty, Rishika & Kobayashi, Lindsay & Jock, Janet & Wing, Coady & Chen, Xiwei & Phillips, Meredith & Berkman, Lisa & Kahn, Kathleen & Kabudula, Chodziwadziwa & Rosenberg, Molly. (2024). Child support grant expansion and cognitive function among women in rural South Africa: Findings from a natural experiment in the HAALSI cohort. PLOS ONE. 19. e0297673. 10.1371/journal.pone.0297673. 
      5. Jock, Janet & Beidelman, Erika & Kobayashi, Lindsay & Tollman, Stephen & Phillips, Meredith & Kabudula, Chodziwadziwa & Rosenberg, Molly. (2024). The Impact of Old Age Pension Eligibility on Alcohol Consumption: Evidence From a Population-Based Study in Rural South Africa. Innovation in Aging. 8. 10.1093/geroni/igad136. 
      6. Beidelman, Erika & Bärnighausen, Till & Wing, Coady & Tollman, Stephen & Phillips, Meredith & Rosenberg, Molly. (2023). Disease awareness and healthcare utilization in rural South Africa: a comparative analysis of HIV and diabetes in the HAALSI cohort. BMC Public Health. 23. 10.1186/s12889-023-17043-2. 
      7. Phillips, Meredith & Kobayashi, Lindsay & Chakraborty, Rishika & Wagner, Ryan & Mahlalela, Nomsa & Brown, Joshua & Harezlak, Jaroslaw & Ludema, Christina & Rosenberg, Molly. (2023). Number of children and mid- to later-life cognitive function and cognitive impairment in rural South Africa: Evidence from “Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa” (HAALSI). 10.1101/2023.09.25.23296101.
      8. Chakraborty, Rishika & Kobayashi, Lindsay & Jock, Janet & Wing, Coady & Chen, Xiwei & Phillips, Meredith & Berkman, Lisa & Kahn, Kathleen & Kabudula, Chodziwadziwa & Rosenberg, Molly. (2023). Child Support Grant expansion and cognitive function among women in rural South Africa: findings from a natural experiment in HAALSI cohort. medRxiv : the preprint server for health sciences. 10.1101/2023.02.18.23286130.
      9. Phillips, Meredith & Kobayashi, Lindsay & Chakraborty, Rishika & Kabudula, Chodziwadziwa & Harezlak, Jaroslaw & Ludema, Christina & Rosenberg, Molly. (2022). Estimating the association between parity and mid‐ to later‐life cognitive function in rural South Africa: Evidence from “Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa” (HAALSI). Alzheimer’s & Dementia. 18. 10.1002/alz.062318.
      10. Beidelman, Erika & Bärnighausen, Till & Wing, Coady & Tollman, Stephen & Phillips, Meredith & Rosenberg, Molly. (2022). HIV Status Knowledge and Healthcare Utilization in Rural South Africa: An illustrative comparison of HIV and Diabetes in the HAALSI Cohort. 10.21203/rs.3.rs-2306892/v1.
      11. Duran, Tugce & Woo, Ellen & Otero, Diana & Risacher, Shannon & Stage, Eddie & Bharthur, Apoorva & Nho, Kwangsik & West, John & Phillips, Meredith & Goukasian, Naira & Hwang, Bum-Soon & Apostolova, Liana. (2022). Associations between Cortical Thickness and Metamemory in Alzheimer’s Disease. Brain Imaging and Behavior. 16. 1-9. 10.1007/s11682-021-00627-0.
      12. Mayo-Wilson, Evan & Phillips, Meredith & Connor, Avonne & Vander Ley, Kelly & Naaman, Kevin & Helfand, Mark. (2021). Peer review reduces spin in PCORI research reports. Research Integrity and Peer Review. 6. 10.1186/s41073-021-00119-1.
      13. Adams, Zachary & Grant, Miyah & Hupp, Samantha & Scott, Taylor & Feagans, Amanda & Phillips, Meredith & Bixler, Kristy & Nallam, Phani & LaPutt, Dorothy. (2021). Acceptability of an mHealth App for Youth with Substance Use and Mental Health Needs: An Iterative, Mixed Methods Design (Preprint). 10.2196/preprints.30268.
      14. Mayo-Wilson, Evan & Phillips, Meredith & Connor, Avonne & Vander Ley, Kelly & Naaman, Kevin & Helfand, Mark. (2021). Peer review reduces spin in PCORI research reports. 10.31222/osf.io/xknhp.
      15. Stage, Eddie & Svaldi, Diana & Phillips, Meredith & Canela, Victor Hugo & Duran, Tugce & Goukasian, Naira & Risacher, Shannon & Saykin, Andrew & Apostolova, Liana. (2020). Neurodegenerative changes in early- and late-onset cognitive impairment with and without brain amyloidosis. Alzheimer’s Research & Therapy. 12. 10.1186/s13195-020-00647-w.
      16. Phillips, Meredith & Stage,  Jr & Lane, Kathleen A & Gao, Sujuan & Risacher, Shannon & Goukasian, Naira & Saykin, Andrew & Carrillo, Maria & Dickerson, Bradford C & Rabinovici, Gil D & Apostolova, Liana. (2020). Neurodegenerative Patterns of Cognitive Clusters of Early-Onset Alzheimer’s Disease Subjects: Evidence for Disease Heterogeneity. Dementia and Geriatric Cognitive Disorders. 48. 1-12. 10.1159/000504341.
      17. Stage, Eddie & Svaldi, Diana & Phillips, Meredith & Duran, Tugce & Risacher, Shannon & Saykin, Andrew & Apostolova, Liana. (2019). EARLY AND LATE-ONSET ALZHEIMER’S DISEASE AND SUSPECTED NON-ALZHEIMER PATHOPHYSIOLOGY WITHIN THE A/T/N FRAMEWORK. Alzheimer’s & Dementia. 15. P141-P142. 10.1016/j.jalz.2019.06.4296.
      18. Phillips, Meredith & Lane, Kathleen & Svaldi, Diana & Gao, Sujuan & Stage, Eddie & Risacher, Shannon & Saykin, Andrew & Apostolova, Liana. (2018). LONGITUDINAL PATTERNS OF DECLINE IN SUBTYPES OF AMNESTIC EARLY ONSET AD. Alzheimer’s & Dementia. 14. P494-P495. 10.1016/j.jalz.2018.06.469.
      19. Stage, Eddie & Svaldi, Diana & Phillips, Meredith & Risacher, Shannon & Duran, Tugce & Saykin, Andrew & Apostolova, Liana. (2018). [18F]-AV-1451 BINDING PROFILE IN EARLY AND LATE-ONSET ALZHEIMER’S DISEASE AND SUSPECTED NON-ALZHEIMER PATHOPHYSIOLOGY. Alzheimer’s & Dementia. 14. P178-P179. 10.1016/j.jalz.2018.06.2286.
      20. Duran, Tugce & Woo, Ellen & Svaldi, Diana & Risacher, Shannon & Stage, Eddie & Goukasian, Naira & Hwang, Kristy & Nho, Kwangsik & West, John & Phillips, Meredith & Apostolova, Liana. (2018). ASSOCIATIONS BETWEEN CORTICAL THICKNESS AND METAMEMORY IN ALZHEIMER’S DISEASE. Alzheimer’s & Dementia. 14. P46-P47. 10.1016/j.jalz.2018.06.2111.
      21. Apostolova, Liana & Risacher, Shannon & Duran, Tugce & Stage, Eddie & Goukasian, Naira & West, John & Do, Triet & Grotts, Jonathan & Wilhalme, Holly & Nho, Kwangsik & Phillips, Meredith & Elashoff, David & Saykin, Andrew. (2018). Associations of the Top 20 Alzheimer Disease Risk Variants With Brain Amyloidosis. JAMA Neurology. 75. 10.1001/jamaneurol.2017.4198.
      22. Phillips, Meredith & Stage, Eddie & Lane, Kathleen & Gao, Sujuan & Risacher, Shannon & Saykin, Andrew & Apostolova, Liana. (2017). NEURODEGENERATIVE PATTERNS OF COGNITIVE CLUSTERS OF EARLY ONSET AD SUBJECTS: EVIDENCE FOR DISEASE HETEROGENEITY. Alzheimer’s & Dementia. 13. P901-P902. 10.1016/j.jalz.2017.07.315.
      23. Stage, Eddie & Phillips, Meredith & Canela, Victor Hugo & Duran, Tugce & Goukasian, Naira & Rabinovici, Gil & Dickerson, Bradford & Carrillo, Maria & De Santi, Susan & Risacher, Shannon & Saykin, Andrew & Apostolova, Liana. (2017). COMPARING IMAGING PHENOTYPES OF AMNESTIC EARLY VERSUS LATE-ONSET AMYLOID-POSITIVE MILD COGNITIVE IMPAIRMENT AND DEMENTIA ADNI SUBJECTS. Alzheimer’s & Dementia. 13. P759-P760. 10.1016/j.jalz.2017.06.1011.
      24. Stage, Eddie & Phillips, Meredith & Duran, Tugce & Canela, Victor & Rabinovici, Gil & Dickerson, Bradford & Carrillo, Maria & De Santi, Susan & Goukasian, Naira & Risacher, Shannon & Apostolova, Liana. (2017). Brain Atrophy in Early and Late Onset Alzheimer’s Disease and Suspected Non-Alzheimer’s Pathophysiology (P4.098). Neurology. 88. 10.1212/WNL.88.16_supplement.P4.098.
      25. Canela, Victor & Stage, Eddie & Phillips, Meredith & Duran, Tugce & Rabinovici, Gil & Dickerson, Bradford & Carrillo, Maria & De Santi, Susan & Risacher, Shannon & Apostolova, Liana. (2017). Differences in brain metabolism in Early and Late Onset Alzheimer’s Disease and Suspected Non-Alzheimer’s Pathophysiology (P4.099). Neurology. 88. 10.1212/WNL.88.16_supplement.P4.099.
      26. Stage, Eddie & Duran, Tugce & Risacher, Shannon & Goukasian, Naira & Do, Triet & West, John & Wilhalme, Holly & Nho, Kwangsik & Phillips, Meredith & Elashoff, David & Saykin, Andrew & Apostolova, Liana & Disease, Neuroimaging & Initiative,. (2016). The effect of the top 20 Alzheimer disease risk genes on gray-matter density and FDG PET brain metabolism-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/ 4.0/). Diagnosis, Assessment, and Disease Monitoring. 5. 53-66. 10.1016/j.dadm.2016.12.003.
      27. Byram, Jessica & Phillips, Meredith & Latham, Krista & Cale, Cindy & Bush, Gay. (2012). Who’s on Your Shoes? Investigating DNA Profiles From New and Worn Shoes. 
      Meredith Phillips, PhD

      Elana Gloger, PhD

      Postdoctoral Scholar

       

      Elana explores the relationships between inflammation, cognitive function, stress, and health outcomes across different populations, with a focus on aging, repetitive thought, and immune system interactions.
      1. Gloger, E.M., & Suhr, J.A. (2020). Correlates of poor sleep and subsequent misdiagnosis in college students presenting with cognitive complaints. Archives of Clinical Neuropsychology, 35(6), 692-670. https://doi.org/10.1093/arclin/acaa023.
      2. Segerstrom, S.C., Gloger, E.M., Hardy, J.K., &, Crofford, L.R. (2020). Exposure and reactivity to repetitive thought in the neuroticism-distress relationship. Cognitive Therapy and Research, 44(3), 659-667. https://doi.org/10.1007/s10608-020-10078-4.
      3. Gloger, E.M., Smith, G.T., Segerstrom, S.C. (2020). Stress Physiology and Physiometrics. In D.F. Ragin & J. P. Keenan (Eds.), Handbook of Research Methods in Health Psychology (pp. 127-140). Routledge/Taylor & Francis Group. https://doi.org/10.4324/9780429488320-13.
      4. Vohs, K. D., Schmeichel, B. J., Lohmann, S., Gronau, Q., Finley, A. J….Gloger, E.M.…Wagenmakers, E.-J., & Albarracín, D. (2021). A multi-site preregistered paradigmatic test of the ego depletion effect. Psychological Science. 32(10), 1566-1581. https://doi.org/10.1177/0956797621989733
      5. Leger, K. A., Gloger, E. M., Maras, J., & Marshburn, C. K. (2022). Lifetime discrimination and health: The mediating role of daily stress processes. Health Psychology, 41(5), 332–342. https://doi.org/10.1037/hea0001173.
      6. Leger, K.A., Gloger, E.M., Crofford, L.R., McDade, T.W., Segerstrom, S.C. (2022). Inflammation and Sleep Variability in Older Adult Women. Psychosomatic Medicine, 84(9), 1006-1012. https://doi.org/10.1097/PSY.0000000000001130.
      7. Gloger, E.M., Judge, S.J., Reed, R.G., Al-Attar, A., Presnell, S.R., Lutz, C.T., & Segerstrom, S.C. (2022). The role of IFN-gamma-producing senescent T cells in the social functioning of older adults. Brain, Behavior, & Immunity – Health, 25, 100512. https://doi.org/10.1016/j.bbih.2022.100512.
      8. Gloger, E.M., Boggero, I.A., Segerstrom, S.C. (2023). Human Psychoneuroimmunology. In H. Friedman & C. Markey (Eds.), Encyclopedia of Mental Health (3rd ed.) (pp. 184-193). Academic Press. https://doi.org/10.1016/B978-0-323-91497-0.00046-1.
      9. Gloger, E. M., & Segerstrom, S. C. (2024). Repetitive thought, cognition, and systemic inflammation in the midlife in the United States study. Psychology & Health, 39(5), 651-669. https://doi.org/10.1080/08870446.2022.2092104.
      10. Lawrence, K. A., Gloger, E. M., Pinheiro, C., Schmitt, F. A., & Segerstrom, S. C. (2024). Associations between IL-1β, IL-6, and TNFα Polymorphisms and Longitudinal Trajectories of Cognitive Function in Non-Demented Older Adults. Brain, Behavior, & Immunity-Health, 100816. https://doi.org/10.1016/j.bbih.2024.100816.
      Meredith Phillips, PhD

      Shruthi Venkatesh, BS

      MD/PhD Student

      Shruthi's studies focus on investigating biopsychosocial factors influencing patient outcomes in neurodegenerative diseases such as AD, MS, and COVID-19.
      1. These studies focus on COVID-19’s impact on neurological diseases, AI-based diagnostics, and the role of social factors in health outcomes.
      2. Menezes MCS, Hoffmann AF, Tan ALM, Nalbandyan M, Omenn GS, Mazzotti DR,  Hernández-Arango A, Visweswaran S, Venkatesh S, Mandl KD, Bourgeois FT, Lee  JWK, Makmur A, Hanauer DA, Semanik MG, Kerivan LT, Hill T, Forero J, Restrepo C, Vigna M, Ceriana P, Abu-el-rub N, Avillach P, Bellazzi R, Callaci T, Gutiérrez-Sacristán  A, Malovini A, Mathew JP, Morris M, Murthy VL, Buonocore TM, Parimbelli E, Patel LP,  Sáez C, Samayamuthu MJ, Thompson JA, Tibollo V, Xia Z, Kohane IS, Records C for  CC of C 19 by EH. The potential of Generative Pre-trained Transformer 4 (GPT-4) to analyse medical notes in three different languages: a retrospective model-evaluation study. Lancet Digit Heal. 2025;7(1):e35-e43. doi:10.1016/s2589-7500(24)00246-2
      3. Riley C*, Venkatesh S*, Dhand A, et al. Impact of the COVID-19 Pandemic on the Personal Networks and Neurological Outcomes of People With Multiple Sclerosis: Cross-Sectional and Longitudinal Case-Control Study. JMIR Public Heal Surveill. 2024;10:e45429. doi:10.2196/45429.
      4. Santini T, Chen C, Zhu W, Liou JJ, Walker E, Venkatesh S, Farhat N, Sajewski A, Alkhateeb S, Saranathan M, Xia Z, Ibrahim TS. Hippocampal subfields and thalamic nuclei associations with clinical outcomes in multiple sclerosis: An ultrahigh field MRI study. Mult Scler Relat Disord. 2024;86:105520. doi:10.1016/j.msard.2024.105520.
      5. Zhu W, Chen C, Zhang L, Hoyt T, Walker E, Venkatesh S, Zhang F, Qureshi F, Foley JF, Xia Z. Association between serum multi-protein biomarker profile and real-world disability in multiple sclerosis. Brain Commun. 2023;6(1):fcad300. doi:10.1093/braincomms/fcad300
      6. Jakimovski D, Kavak KS, Longbrake EE, Levit E, Perrone CM, Bar-Or A, Benedict RH, Riley CS, Jager PLD, Venkatesh S, Walker ELS, Xia Z, Weinstock-Guttman B, Collaborative MSR to C 19 (MSReCOV). Impact of resilience, social support, and personality traits in patients with neuroinflammatory diseases during the COVID-19 pandemic. Mult Scler Relat Disord. 2022;68:104235. doi:10.1016/j.msard.2022.104235.
      7. Wang L, Venkatesh S, Morris M, Li M, Srivastava R, Visweswaran S, Lopez O, Xia Z, Cai T. Stratification of Alzheimer’s Disease Patients Using Knowledge-Guided Unsupervised Latent Factor Clustering with Electronic Health Record Data. medRxiv [Preprint]. 2024 Dec 26:2024.12.23.24319588. doi: 10.1101/2024.12.23.24319588. PMID: 39763548; PMCID: PMC11703308.
      8. Xia Z, Chikersal P, Venkatesh S, Walker E, Dey A, Goel M. Longitudinal Digital Phenotyping of Multiple Sclerosis Severity Using Passively Sensed Behaviors and Ecological Momentary Assessments. medRxiv [Preprint]. 2024 Dec 8:2024.11.02.24316647. doi: 10.1101/2024.11.02.24316647. PMID: 39677484; PMCID: PMC11643184.
      9. Venkatesh, S., et al. (2024). “A Real-world Investigation of Demographic Disparity in Alzheimer’s Disease Progression (P2-9.003).” Neurology 102(7_supplement_1): 5255.
      10. Chikersal, P., Venkatesh, S., Masown, K., Walker, E., Quraishi, D., Dey, A., … & Xia, Z. (2023, May). Predicting Multiple Sclerosis Outcomes During The COVID-19 Stay-at-Home Period Using Passively Sensed Behaviors. In MULTIPLE SCLEROSIS JOURNAL (Vol. 29, pp. 72-72). 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND: SAGE PUBLICATIONS LTD.
      11. Riku Arakawa, Hiromu Yakura, Vimal Mollyn, Suzanne Nie, Emma Russell, Dustin P. DeMeo, Haarika A. Reddy, Alexander K. Maytin, Bryan T. Carroll, Jill Fain Lehman, and Mayank Goel. 2023. PrISM-Tracker: A Framework for Multimodal Procedure Tracking Using Wearable Sensors and State Transition Information with User-Driven Handling of Errors and Uncertainty. Proc. ACM Interact. Mob. Wearable Ubiquitous Technol. 6, 4, Article 156 (December 2022), 27 pages. https://doi.org/10.1145/3569504
      12. Boorgu DSSK, Venkatesh S, Lakhani CM, Walker E, Aguerre IM, Riley C, Patel CJ, De Jager PL, Xia Z. The impact of socioeconomic status on subsequent neurological outcomes in multiple sclerosis. Mult Scler Relat Disord. 2022 Sep;65:103994. doi: 10.1016/j.msard.2022.103994. Epub 2022 Jun 24. PMID: 35780727; PMCID: PMC9444968.
      13. Levit E, Cohen I, Dahl M, Edwards K, Weinstock-Guttman B, Ishikawa T, Kavak K, Leavitt V, Nelson K, Onomichi K, Bar-Or A, Perrone C, Riley C, Venkatesh S, De Jager PL, Xia Z, Longbrake EE; Multiple Sclerosis Resilience to COVID-19 (MSReCOV) Collaborative. Worsening physical functioning in patients with neuroinflammatory disease during the COVID-19 pandemic. Mult Scler Relat Disord. 2022 Feb;58:103482. doi: 10.1016/j.msard.2021.103482. Epub 2022 Jan 4. PMID: 35016114; PMCID: PMC8742609.
      14. Venkatesh, S., et al. “Association between exposome and subsequent multiple sclerosis outcomes.” MULTIPLE SCLEROSIS JOURNAL. Vol. 27. No. 2_ SUPPL. 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND: SAGE PUBLICATIONS LTD, 2021.
      15. Mani A, Santini T, Puppala R, Dahl M, Venkatesh S, Walker E, DeHaven M, Isitan C, Ibrahim TS, Wang L, Zhang T, Gong E, Barrios-Martinez J, Yeh FC, Krafty R, Mettenburg JM, Xia Z. Applying Deep Learning to Accelerated Clinical Brain Magnetic Resonance Imaging for Multiple Sclerosis. Front Neurol. 2021 Sep 27;12:685276. doi: 10.3389/fneur.2021.685276. PMID: 34646227; PMCID: PMC8504490.
      16. Mathew T, Thomas K, K John S, Venkatesh S, Nadig R, Badachi S, Souza DD, Sarma G, Parry GJ. Effective Early Treatment of AChR Antibody-Positive Myasthenia Gravis with Rituximab; the Experience from a Neuroimmunology Clinic in a Developing Country. J Cent Nerv Syst Dis. 2021 May 17;13:11795735211016080. doi: 10.1177/11795735211016080. PMID: 34045914; PMCID: PMC8135199.
      17. Levin SN, Venkatesh S, Nelson KE, Li Y, Aguerre I, Zhu W, Masown K, Rimmer KT, Diaconu CI, Onomichi KB, Leavitt VM, Levine LL, Strauss-Farber R, Vargas WS, Banwell B, Bar-Or A, Berger JR, Goodman AD, Longbrake EE, Oh J, Weinstock-Guttman B, Thakur KT, Edwards KR, Riley CS, Xia Z, De Jager PL; Multiple Sclerosis Resilience to COVID-19 (MSReCOV) Collaborative. Manifestations and impact of the COVID-19 pandemic in neuroinflammatory diseases. Ann Clin Transl Neurol. 2021 Apr;8(4):918-928. doi: 10.1002/acn3.51314. Epub 2021 Feb 22. PMID: 33616290; PMCID: PMC8013889.
      18. Levin SN, Riley CS, Dhand A, White CC, Venkatesh S, Boehm B, Nassif C, Socia L, Onomichi K, Leavitt VM, Levine L, Heyman R, Farber RS, Vargas WS, Xia Z, De Jager PL. Association of social network structure and physical function in patients with multiple sclerosis. Neurology. 2020 Sep 15;95(11):e1565-e1574. doi: 10.1212/WNL.0000000000010460. Epub 2020 Aug 7. PMID: 32769139; PMCID: PMC7713741.
      19. Mathew T, Venkatesh S, Srinivas M. The approach and management of bruxism in Alzheimer’s disease: An under-recognized habit that concerns caregivers (innovative practice). Dementia (London). 2020 Feb;19(2):461-463. doi: 10.1177/1471301217694249. Epub 2017 Feb 15. PMID: 28201931.
      20. Mathew T, Thomas K, Shivde S, Venkatesh S, Rockey SM. Post herpes zoster infection neuromyelitis optica spectrum disorder. Mult Scler Relat Disord. 2017 Nov;18:93-94. doi: 10.1016/j.msard.2017.09.022. Epub 2017 Sep 27. PMID: 29141830.
      21. Menezes MCS, Hoffmann AF, Tan ALM, Nalbandyan M, Omenn GS, Mazzotti DR, Hernández-Arango A, Visweswaran S, Venkatesh S, Mandl KD, Bourgeois FT, Lee JWK, Makmur A, Hanauer DA, Semanik MG, Kerivan LT, Hill T, Forero J, Restrepo C, Vigna M, Ceriana P, Abu-El-Rub N, Avillach P, Bellazzi R, Callaci T, Gutiérrez-Sacristán A, Malovini A, Mathew JP, Morris M, Murthy VL, Buonocore TM, Parimbelli E, Patel LP, Sáez C, Samayamuthu MJ, Thompson JA, Tibollo V, Xia Z, Kohane IS; Consortium for Clinical Characterization of COVID-19 by Electronic Health Records. The potential of Generative Pre-trained Transformer 4 (GPT-4) to analyse medical notes in three different languages: a retrospective model-evaluation study. Lancet Digit Health. 2025 Jan;7(1):e35-e43. doi: 10.1016/S2589-7500(24)00246-2. PMID: 39722251. 
      Richard Xu, ScM

      Richard Xu, ScM

      MPH/PhD Student

       

      In his work, Richard explores the early-life origins and genetic factors of cardiometabolic and neurological diseases, focusing on maternal influences, biomarkers, and prevention strategies for conditions like stroke, obesity, and Parkinsonian syndromes.
      1. Hong, Xiumei1; Xu, Richard2; Mi, Michael Y.3; Farrell, Laurie A.3; Wang, Guoying1; Liang, Liming4,5; Gerszten, Robert E.3; Hu, Frank B.4,6,7,*; Wang, Xiaobin1,8,*. Integration of proteomics with prospective birth cohort to elucidate early life origins of cardiometabolic diseases: rationale, study design, lab assay, and quality control. Precision Nutrition 3(3):p e00085, September 2024. | DOI: 10.1097/PN9.0000000000000085
      2. Shurer J, Ivancic M, Nesspor V, Schmidt M, Li M, Lin YT, Schumock G, Xu R, Sklerov M, Pantelyat A. Determinants of care partner burden in atypical Parkinsonian syndromes: A retrospective, multi-center analysis. Clin Park Relat Disord. 2024 Jul 17;11:100266. doi: 10.1016/j.prdoa.2024.100266. PMID: 39149560; PMCID: PMC11325345.
      3. Xu R, Tian Q, Marron MM, Ferrucci L, Yao S, Kim S, Shah RV, Murthy VL, Newman AB, Miljkovic I, Rosano C. Metabolomic insight into the link of intermuscular fat with cognitive performance: the Health ABC Study. Geroscience. 2025 Feb 20. doi: 10.1007/s11357-025-01559-z. Epub ahead of print. PMID: 39976843.
      4. Richard Xu, Megan Marron, Shanshan Yao, Seyoung Kim, Ravi Shah, Venkatesh Murthy, Anne Newman, Caterina Rosano, INTER-RELATIONSHIPS OF CIRCULATING PLASMA METABOLITES, INTERMUSCULAR FAT, AND PROCESSING SPEED: HEALTH ABC STUDY, Innovation in Aging, Volume 8, Issue Supplement_1, December 2024, Pages 1143–1144, https://doi.org/10.1093/geroni/igae098.3667
      5. Xu R, Hong X, Ladd-Acosta C, Buckley JP, Choi G, Wang G, Hou W, Wang X, Liang L, Ji H. Contrasting Association of Maternal Plasma Biomarkers of Smoking and 1-Carbon Micronutrients with Offspring DNA Methylation: Evidence of Aryl Hydrocarbon Receptor Repressor Gene-Smoking-Folate Interaction. J Nutr. 2023 Aug;153(8):2339-2351. doi: 10.1016/j.tjnut.2023.05.002. Epub 2023 May 6. PMID: 37156443; PMCID: PMC10447613.
      6. Wang, G., Xu, R., Zhang, B. et al. Impact of intrauterine exposure to maternal diabetes on preterm birth: fetal DNA methylation alteration is an important mediator. Clin Epigenet 15, 59 (2023). https://doi.org/10.1186/s13148-023-01473-1
      7. Hou W, Zhang M, Ji Y, Hong X, Wang G, Xu R, Liang L, Saria S, Ji H. A prospective birth cohort study of maternal prenatal cigarette smoking assessed by self-report and biomarkers on childhood risk of overweight or obesity. Precis Nutr. 2022 Dec 7;1(3):e00017. doi: 10.1097/PN9.0000000000000017. PMID: 37744083; PMCID: PMC10035292.
      8. Huang W, Igusa T, Wang G, Buckley JP, Hong X, Bind E, Steffens A, Mukherjee J, Haltmeier D, Ji Y, Xu R, Hou W, Tina Fan Z, Wang X. In-utero co-exposure to toxic metals and micronutrients on childhood risk of overweight or obesity: new insight on micronutrients counteracting toxic metals. Int J Obes (Lond). 2022 Aug;46(8):1435-1445. doi: 10.1038/s41366-022-01127-x. Epub 2022 May 19. PMID: 35589962; PMCID: PMC9329205.
      9. Huang X, Cao T, Chen L, Li J, Tan Z, Xu B, Xu R, Song Y, Zhou Z, Wang Z, Wei Y, Zhang Y, Li J, Huo Y, Qin X, Wu Y, Wang X, Wang H, Cheng X, Xu X, Liu L. Novel Insights on Establishing Machine Learning-Based Stroke Prediction Models Among Hypertensive Adults. Front Cardiovasc Med. 2022 May 6;9:901240. doi: 10.3389/fcvm.2022.901240. PMID: 35600480; PMCID: PMC9120532.
      10. Hu L, Li Y, Liu Z, Fan F, Xu B, Xu R, Song Y, Chen P, Wei Y, Jia J, Zhang L, Weng H, Shi Q, Zhang N, Wang X, Zheng B, Zhang Y, Li J. Association of Plasma Vitamin B6 With Coronary Heart Disease in Patients Undergoing Diagnostic Coronary Angiography: New Insight on Sex Differences. Front Cardiovasc Med. 2021 Dec 15;8:789669. doi: 10.3389/fcvm.2021.789669. PMID: 34977195; PMCID: PMC8714911.
      11. Xu R, Hong X, Zhang B, Huang W, Hou W, Wang G, Wang X, Igusa T, Liang L, Ji H. DNA methylation mediates the effect of maternal smoking on offspring birthweight: a birth cohort study of multi-ethnic US mother-newborn pairs. Clin Epigenetics. 2021 Mar 4;13(1):47. doi: 10.1186/s13148-021-01032-6. PMID: 33663600; PMCID: PMC7931602.
      12. Song Y, Li J, Liu L, Xu R, Zhou Z, Xu B, Lin T, Chen P, Li H, Li Y, Liu C, Huang X, Wang B, Zhang Y, Li J, Huo Y, Ren F, Xu X, Zhang H, Qin X. Plasma Vitamin E and the Risk of First Stroke in Hypertensive Patients: A Nested Case-Control Study. Front Nutr. 2021 Nov 3;8:734580. doi: 10.3389/fnut.2021.734580. PMID: 34805240; PMCID: PMC8595403.
      13. Huang, Xiao and Cao, Tianyu and Chen, Liangziqian and Wu, Hanyu and Li, Junpei and Tan, Ziheng and Xu, Benjamin and Xu, Richard and Song, Yun and Zhou, Ziyi and Wang, Zhuo and Wei, Yaping and Zhang, Yan and Li, Jianping and Huo, Yong and Qin, Xianhui and Wu, Yanqing and Wang, Xiaobin and Wang, Hong and Xu, Xiping and Cheng, Xiaoshu and Liu, Lishun, Predicting Stroke Risk in a Chinese Hypertensive Population Using Machine Learning. Available at SSRN: https://ssrn.com/abstract=3911099
      14. Hu H, Li H, Huang X, Bao H, Song Y, Wang B, Liu C, Xu R, Liu L, Wang X, Huo Y, Xu X, Cheng X, Qin X, Li P. Association of self-reported sleep duration and quality with BaPWV levels in hypertensive patients. Hypertens Res. 2020 Dec;43(12):1392-1402. doi: 10.1038/s41440-020-0509-y. Epub 2020 Jul 16. PMID: 32678321; PMCID: PMC7671938.
      15. Kong X, Huang X, Zhao M, Xu B, Xu R, Song Y, Yu Y, Yang W, Zhang J, Liu L, Zhang Y, Tang G, Wang B, Hou FF, Li P, Cheng X, Zhao S, Wang X, Qin X, Li J, Huo Y. Platelet Count Affects Efficacy of Folic Acid in Preventing First Stroke. J Am Coll Cardiol. 2018 May 15;71(19):2136-2146. doi: 10.1016/j.jacc.2018.02.072. PMID: 29747834.
      16. Wang H, Xu BP, Xu RB, Walker SO, Wang G. Joint effect of maternal plasma homocysteine and prepregnancy obesity on child blood pressure: a prospective birth cohort study. Int J Obes (Lond). 2017 Sep;41(9):1447-1453. doi: 10.1038/ijo.2017.109. Epub 2017 May 3. PMID: 28465603; PMCID: PMC5585041.
      17. Kong, X, Xu, B, Xu, R. et al. EFFICACY OF FOLIC ACID SUPPLEMENTATION ON THE REDUCTION OF STROKE RISK: INTERACTION WITH PLATELET COUNT. JACC. 2017 Mar, 69 (11_Supplement) 1870.https://doi.org/10.1016/S0735-1097(17)35259-2
      18. Xu RB, Kong X, Xu BP, Song Y, Ji M, Zhao M, Huang X, Li P, Cheng X, Chen F, Zhang Y, Tang G, Qin X, Wang B, Hou FF, Dong Q, Chen Y, Yang T, Sun N, Li X, Zhao L, Ge J, Ji L, Huo Y, Li J. Longitudinal association between fasting blood glucose concentrations and first stroke in hypertensive adults in China: effect of folic acid intervention. Am J Clin Nutr. 2017 Mar;105(3):564-570. doi: 10.3945/ajcn.116.145656. Epub 2017 Jan 25. PMID: 28122783. 

      Kailyn Witonsky, MS, MSTP

      MD/PhD Student

      From joint pain and physical activity in older adults to neurobiological insights on addiction, migraine, and brain responses in animals, Kailyn explores a wide range of health issues, unraveling everything from familial patterns in mood disorders to the neural circuitry of craving and stress.

      1. Witonsky, K., Zhu, X., Rosso, A.L., Newman, A. and Rosano, C. (2025), Joint Pain and Leisure-Time Physical Activity: Cross-Sectional Findings From the Cardiovascular Health Study. Health Science Reports, 8: e70367. https://doi.org/10.1002/hsr2.70367

      2. Lateef, Tarannum & Witonsky, Kailyn & He, Jianping & Merikangas, Kathleen. (2019). Headaches and sleep problems in US adolescents: Findings from the National Comorbidity Survey – Adolescent Supplement (NCS-A). Cephalalgia. 39. 033310241983546. 10.1177/0333102419835466.

      3. Lateef, Tara & cui, lihong & Zipunnikov, Vadim & Witonsky, Kailyn & Xiao, MIke & Merikangas, Kathleen. (2019). ‘Sleep Disturbance and Environmental Reactivity as Potential Mechanisms for Comorbidity of Mood and Anxiety Disorders with Migraine (P4.10-007). Neurology. 92. 10.1212/WNL.92.15_supplement.P4.10-007.

      4. Lateef, Tarannum & Cui, Lihong & Witonsky, Kailyn & Merikangas, Kathleen. (2019). Familial Transmission of Migraine and Mood Disorders-Evidence from a High Risk Study (S59.005). Neurology. 92. 10.1212/WNL.92.15_supplement.S59.005.

      5. Rubio, F. Javier & Quintana-Feliciano, Richard & Warren, Brandon & Li, Xuan & Witonsky, Kailyn & Valle, Frank & Selvam, Pooja & Caprioli, Daniele & Venniro, Marco & Bossert, Jennifer & Shaham, Yavin & Hope, Bruce. (2018). Prelimbic cortex is a common brain area activated during cue-induced reinstatement of cocaine and heroin seeking in a polydrug self-administration rat model. European Journal of Neuroscience. 49. 10.1111/ejn.14203.

      6. Hamedani, Ali & Witonsky, Kailyn & Cosico, Mahgenn & Rennie, Robert & Xiao, Riu & Sheldon, Claire & Paley, Grace & Mccormack, Shana & Liu, Geraldine & Friedman, Deborah & Liu, Grant & Szperka, Christina. (2018). Headache Characteristics in Children With Pseudotumor Cerebri Syndrome, Elevated Opening Pressure Without Papilledema, and Normal Opening Pressure: A Retrospective Cohort Study. Headache: The Journal of Head and Face Pain. 58. 10.1111/head.13362.

      7. Li, Xuan & Witonsky, Kailyn & Lofaro, Olivia & Surjono, Felicia & Zhang, Jianjun & Bossert, Jennifer & Shaham, Yavin. (2018). Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving. The Journal of Neuroscience. 38. 2873-17. 10.1523/JNEUROSCI.2873-17.2018.

      8. Li, Xuan & Carreria, Maria & Witonsky, Kailyn & Zeric, Tamara & Lofaro, Olivia & Bossert, Jennifer & Zhang, Jianjun & Surjono, Felicia & Richie, Christopher & Harvey, Brandon & Son, Hyeon & Cowan, Christopher & Shaham, Yavin. (2017). Role of Dorsal Striatum Histone Deacetylase 5 in Incubation of Methamphetamine Craving. Biological Psychiatry. 84. 10.1016/j.biopsych.2017.12.008.

      9. Baugh, Alexander & Witonsky, Kailyn & Davidson, Sarah & Hyder, Laura & Hau, Michaela & van Oers, Kees. (2017). Novelty induces behavioural and glucocorticoid responses in a songbird artificially selected for divergent personalities. Animal Behaviour. 130. 221-231. 10.1016/j.anbehav.2017.06.028.