eBRAIN Studies

Research

Focusing on the application of epidemiology methods and cutting-edge neuroimaging methodologies in population and clinical studies to enhance etiological research and evaluation of specific therapies in the disorders of the central nervous system.

PI of the MRI project

C. Rosano

Goal

Identify brain networks and risk factors important for maintaining mobility.

327 older adults living in the community, 79-89 yrs old, 60% women participants of the Health ABC study since 1996 (PI of main study: Dr. Newman). This MRI study begun in 2006-07. The participants are being followed yearly through 2011-12.

PIs

C. Rosano, H.J. Aizenstein

Goal

Identify markers of resilience to aging and protective factors.

Approx 250 Healthy Brain Project 1 survivors, they are now 89-99 years old. They are receiving a 2nd MRI in 2010-11 and will be followed through 2014-15. MRI include studies of brain activation and brain blood perfusion.

PI

C. Rosano

Goal

Identify markers and risk factors for accelerated brain aging.

Approx. 200 middle aged T1D men and women who have participated to the EDC study since 1985 (PI: t. Orchard) , will receive MRI and NP tests in 2011. Patients will be followed through 2014. MRI include studies of brain activation and brain blood perfusion. We will examine these results starting from 2012. Data will be compared to MRI of older adults and of middle aged without diabetes.

PI

C. Rosano, H.J. Aizenstein

Goal

Can the brain modify the response to physical activity in sedentary old adults?

Frail elderly (mean age 75) participants of a randomized control study called LIFE-MAIN, (PIs: Pahor/Newman/Studenski) receive a 7Tesla MRI and have been followed for 2 years. This type of MRI is very powerful in that it allows seeing the granular cell of the dentate gyrus within the hippocmapus with the highest possible level of detail.

PIs

C. Rosano and K. Erickson

Goal

Can a 3 months dance program improve brain function and structure?

70 post-menopausal women participating in the Dance dance revolution study (DDR) (PI: Studenski)